Gene Report

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Basic Info

Approved Symbol	OLFM3
Symbol Alias	NOE3
Approved Name	olfactomedin 3
Name Alias	optimedin
Location	1p22
Position	chr1:101802574-101997030, -1
External Links	HGNC: 17990 Entrez Gene: 118427 Ensembl: ENSG00000118733 UCSC: uc001duf.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs1105280	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045202	synapse	cellular component	IEA	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030054	cell junction	cellular component	IEA	88
GO:0005615	extracellular space	cellular component	IEA	85
GO:0005515	protein binding	molecular function	IPI[12019210]	563
GO:0005794	Golgi apparatus	cellular component	IEA	60
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	cellular component	IEA	8
GO:0042462	eye photoreceptor cell development	biological process	IEA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
OLFM3	MYOC	NO	in vitro;in vivo	12019210

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1105280	chr1:101997183 - 101997183(1)	upstream_gene_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p21	chr1:94300000-106700000	1 (0/1/0)
1p22-p21	chr1:84400000-106700000	1 (0/0/1)
1p22-21	chr1:84400000-106700000	1 (0/0/1)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:101802574..101997030 View in gBrowse