Gene Report

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Basic Info

Approved Symbol	FOXN3
Previous Symbol	C14orf116, CHES1
Approved Name	forkhead box N3
Previous Name	chromosome 14 open reading frame 116, "checkpoint suppressor 1"
Location	14q32.11
Position	chr14:89124871-89619149, -1
External Links	HGNC: 1928 Entrez Gene: 1112 Ensembl: ENSG00000053254 UCSC: uc001xxo.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0004. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IC[16102918]	283
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[16102918]	43
GO:0007095	mitotic G2 DNA damage checkpoint	biological process	IGI[9154802]	1
GO:0005515	protein binding	molecular function	IPI[16102918]	563
GO:0008022	protein C-terminus binding	molecular function	IPI[16951149]	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FOXN3	EXOSC8	NO	yeast 2-hybrid	15231747

Related other genetic factors

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17125698	chr14:89329326 - 89329326(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs3825669	chr14:89337932 - 89337932(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7141800	chr14:89338163 - 89338163(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3783855	chr14:89332044 - 89332044(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs17125700	chr14:89329967 - 89329967(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs17125695	chr14:89328985 - 89328985(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12587725	chr14:89327714 - 89327714(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3825670	chr14:89327142 - 89327142(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10151835	chr14:89309840 - 89309840(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11159898	chr14:89308644 - 89308644(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:89124871..89619149 View in gBrowse