Gene Report

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Basic Info

Approved Symbol	ROR1
Previous Symbol	NTRKR1
Approved Name	receptor tyrosine kinase-like orphan receptor 1
Location	1p31.3
Position	chr1:63774022-64181498, 1
External Links	HGNC: 10256 Entrez Gene: 4919 Ensembl: ENSG00000185483 UCSC: uc001dbj.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2009	SNP: rs11208285	SNPs with the strongest statistical evidence for genetic background effects included rs11208285 in ROR1 at 1p31.3 (P=1.4E-06), rs4657247 in RGS5 at 1q23.3 (P=4.1E-06), and rs7078071 in BTBD16 at 10q26.13 (P=4.5E-06).	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043235	receptor complex	cellular component	IDA[23382219]	20
GO:0005886	plasma membrane	cellular component	TAS[1334494]	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[1334494]	158
GO:0004714	transmembrane receptor protein tyrosine kinase activity	molecular function	IEA	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IEA	16
GO:0005515	protein binding	molecular function	IPI[22439932]	563
GO:0005737	cytoplasm	cellular component	TAS[8875995]	322
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	IEA; TAS[8875995]	12
GO:0005524	ATP binding	molecular function	IEA	118
GO:0017147	Wnt-protein binding	molecular function	IPI[18287027]	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:63774022..64181498 View in gBrowse