Gene Report

Basic Info
Approved Symbol NRXN1
Symbol Alias KIAA0578, Hs.22998
Approved Name neurexin 1
Location 2p16.3
Position chr2:49918505-51225575, -1
External Links HGNC: 8008
Entrez Gene: 9378
Ensembl: ENSG00000179915
UCSC: uc032nmr.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Noor A., 2014 Interestingly, in four unrelated BD cases, we identified CNVs involving members of the neurexin family of genes, including a loss and a gain - both exonic - at NRXN1 (also see de novo loss at NRXN1 in another BD subject, below), an intronic deletion in NRXN3 and a partial duplication (exonic) of NRXN2. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 59)

GO terms by PBA (count: 8)

GO terms by database search (count: 51)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 26)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr2:49918505..51225575 View in gBrowse
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