Gene Report

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Basic Info

Approved Symbol	COL28A1
Approved Name	collagen, type XXVIII, alpha 1
Location	7p21.3
Position	chr7:7356203-7535853, -1
External Links	HGNC: 22442 Entrez Gene: 340267 Ensembl: ENSG00000215018 UCSC: uc003src.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0005. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	IEA	7
GO:0007155	cell adhesion	biological process	IEA	42

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0005576	extracellular region	cellular component	TAS	97
GO:0005581	collagen trimer	cellular component	IEA	4
GO:0005604	basement membrane	cellular component	IEA	5
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	8
GO:0010951	negative regulation of endopeptidase activity	biological process	IEA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p21.3	chr7:7200000-13700000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:7356203..7535853 View in gBrowse