BDgene

Gene Report

Basic Info
Approved Symbol GRM2
Symbol Alias GPRC1B, mGlu2, MGLUR2
Approved Name glutamate receptor, metabotropic 2
Location 3p21.2
Position chr3:51707070-51718613, 1
External Links HGNC: 4594
Entrez Gene: 2912
Ensembl: ENSG00000164082
UCSC: uc010hlv.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Tsunoka, T.,2009 SNP: rs12487957, rs3821829, rs4687771 We did not detect any association between GRM2 and MDD, BP or the fluvoxamine therapeutic response in MDD in the allele/genotype-wise or haplotype-wise analysis. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 4)

GO terms by database search (count: 13)


Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)


Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 7)

Literature-origin SNPs (count: 3)

LD-proxies (count: 4)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)


Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)


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Region: chr3:51707070..51718613 View in gBrowse
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