Gene Report

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Basic Info

Approved Symbol	TUBA1B
Symbol Alias	K-ALPHA-1
Approved Name	tubulin, alpha 1b
Name Alias	tubulin, alpha, ubiquitous
Location	12q13.12
Position	chr12:49127782-49131397, -1
External Links	HGNC: 18809 Entrez Gene: 10376 Ensembl: ENSG00000123416 UCSC: uc001rtm.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014		P = 0.000002. The most significantly associated circadian gene with BPD is the TUBA1B gene on chromosome 12 (P=0.000002).	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005198	structural molecule activity	molecular function	TAS[12090300]	14

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006457	protein folding	biological process	TAS	7
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[21753002]	25
GO:0005874	microtubule	cellular component	IDA[21525035]; TAS[12090300]	24
GO:0005525	GTP binding	molecular function	IEA	20
GO:0071353	cellular response to interleukin-4	biological process	IEA	4
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0000226	microtubule cytoskeleton organization	biological process	IEA	9
GO:0030705	cytoskeleton-dependent intracellular transport	biological process	TAS[12090300]	2
GO:0051301	cell division	biological process	TAS[12090300]	20
GO:0003924	GTPase activity	molecular function	IEA	14
GO:0007017	microtubule-based process	biological process	TAS[12090300]	2
GO:0051084	'de novo' posttranslational protein folding	biological process	TAS	1
GO:0005515	protein binding	molecular function	IPI[11698390]	563
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005200	structural constituent of cytoskeleton	molecular function	IEA	9
GO:0051258	protein polymerization	biological process	IEA	3
GO:0005881	cytoplasmic microtubule	cellular component	IEA	2
GO:0003725	double-stranded RNA binding	molecular function	IDA[21266579]	9

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04540	Gap junction	15

ID	Name	No. of Genes in BDgene	Brief Description
hsa05131	EPEC	6
hsa05130	Pathogenic Escherichia coli infection	6

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TUBA1B	PTP4A1	NO	in vitro	12235145
TUBA1B	MYC	NO	in vitro;in vivo	7651436
TUBA1B	PXN	NO	in vitro;in vivo;yeast 2-hybrid	10840040
TUBA1B	SNAP91	YES	in vitro	12750376
TUBA1B	PFDN5	NO	in vivo	11535601
TUBA1B	NFKBIA	NO	in vivo	9372968
TUBA1B	SIAH1	NO	yeast 2-hybrid	11146551
TUBA1B	HDAC6	NO	in vitro;in vivo;yeast 2-hybrid	12606581
TUBA1B	MINK1	NO	yeast 2-hybrid	15032605
TUBA1B	TUBG1	NO	in vitro	11082048
TUBA1B	EPN2	NO	in vitro;in vivo	12750376

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:49127782..49131397 View in gBrowse