Gene Report

Basic Info
Approved Symbol CCL2
Previous Symbol SCYA2
Symbol Alias MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434
Approved Name chemokine (C-C motif) ligand 2
Previous Name small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
Name Alias monocyte chemotactic protein 1, homologous to mouse Sig-je, "monocyte chemoattractant protein-1", "monocyte chemotactic and activating factor", "monocyte secretory protein JE", "small inducible cytokine subfamily A (Cys-Cys), member 2"
Location 17q11.2-q21.1
Position chr17:34255218-34257203, 1
External Links HGNC: 10618
Entrez Gene: 6347
Ensembl: ENSG00000108691
UCSC: uc002hhy.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Altamura, A. C., 2010 Other variant: SCYA2_A-2518G The present preliminary results, though limited by the relatively small sample, suggest a possible role of the SCYA2 in conferring susceptibility to BD. Positive Comment on Study
Roh, M. S., 2007 Other variant: MCP-1_A-2518G We found no association between MCP-1 and BD in Koreans. Negative Comment on Study
Djurovic, S.,2010 SNP: rs11080256, rs11652429, rs11658512, rs4328493 No significant association of this gene was observed in BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 98)

GO terms by PBA (count: 5)

GO terms by database search (count: 93)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)

Gene related interactors from protein-protein interactions data in HPRD (count: 10)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 6)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 3)

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Region: chr17:34255218..34257203 View in gBrowse
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