Gene Report

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Basic Info

Approved Symbol	SST
Symbol Alias	SMST
Approved Name	somatostatin
Name Alias	somatostatin-14, "somatostatin-28", "prepro-somatostatin"
Location	3q28
Position	chr3:187668906-187670399, -1
External Links	HGNC: 11329 Entrez Gene: 6750 Ensembl: ENSG00000157005 UCSC: uc003frn.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs1365111, rs6797699	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS[9437026]	116
GO:0005179	hormone activity	molecular function	TAS[9886848]	12
GO:0007586	digestion	biological process	TAS[6145156]	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043200	response to amino acid	biological process	IEA	6
GO:0005576	extracellular region	cellular component	TAS	97
GO:0008628	hormone-mediated apoptotic signaling pathway	biological process	TAS[8961277]	2
GO:0042493	response to drug	biological process	IEA	57
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[9437026]	23
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0048545	response to steroid hormone	biological process	IEA	2
GO:0006972	hyperosmotic response	biological process	IEA	2
GO:0030334	regulation of cell migration	biological process	IEA	9
GO:0007267	cell-cell signaling	biological process	TAS[6145156]	29
GO:0007584	response to nutrient	biological process	TAS[6145156]	10
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9886848]	41
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8405411]	64
GO:0009408	response to heat	biological process	IEA	12
GO:0005615	extracellular space	cellular component	TAS[9437026]	85

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SST	SSTR3	NO	in vivo	1337145
SST	SSTR4	NO	in vivo	8100352
SST	SSTR5	YES	in vivo	7908405
SST	SSTR1	YES	in vivo	1346068
SST	SSTR2	NO	in vivo	1346068

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6797699	chr3:187667457 - 187667457(1)	downstream_gene_variant	1(0/1/0)
rs1365111	chr3:187675118 - 187675118(1)	upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs12638067	chr3:187674130 - 187674130(1)	upstream_gene_variant
rs2114118	chr3:187673460 - 187673460(1)	upstream_gene_variant
rs2162189	chr3:187673273 - 187673273(1)	upstream_gene_variant
rs2162188	chr3:187673191 - 187673191(1)	upstream_gene_variant
rs6789745	chr3:187675206 - 187675206(1)	upstream_gene_variant
rs12635290	chr3:187674144 - 187674144(1)	upstream_gene_variant
rs6794112	chr3:187673120 - 187673120(1)	upstream_gene_variant
rs13434247	chr3:187665556 - 187665556(1)	downstream_gene_variant
rs10513817	chr3:187666998 - 187666998(1)	downstream_gene_variant
rs7624906	chr3:187671848 - 187671848(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q27	chr3:183000000-188200000	2 (0/0/2)
3q27-28	chr3:183000000-192600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
2894462	229	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
21226980	MDD subjects demonstrated reduced SST mRNA expression in the dorsolateral prefrontal cortex.	Pos	SST
24391664	GPLS genes significantly dysregulated in anterior cingulate cortex by microarray	Pos	SST
21912391	genes significantly affected in female MDD subjects	Pos	SST

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Region: chr3:187668906..187670399 View in gBrowse