Gene Report

Basic Info
Approved Symbol RORB
Symbol Alias RZRB, NR1F2, ROR-BETA
Approved Name RAR-related orphan receptor B
Location 9q22
Position chr9:74497365-74693177, 1
External Links HGNC: 10259
Entrez Gene: 6096
Ensembl: ENSG00000198963
UCSC: uc004ajh.3
No. of Studies 4 (Positive: 3; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Lai, Y. C., 2015 SNP: rs17611535, rs1327836, rs499922 Our results support for the involvement of RORs genes in the risk of developing BD. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.37. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
McGrath, C. L.,2009 SNP: rs1157358, rs3750420, rs3903529, rs7022435
Haplotype: rs11144033 - rs3903529 - rs968357(), rs17684881 - rs17612218 - rs11144020 - rs17612778 - rs17612874 - rs17691363 - rs10869430(), rs7022435 - rs17691614 - rs7032677()
We report that four intronic RORB SNPs showed positive associations with the pediatric bipolar phenotype that survived Bonferroni correction for multiple comparisons in the case-control sample.Three RORB haplotype blocks implicating an additional 11 SNPs were also associated with the disease in the case-control sample.Our findings suggest that clock genes in general and RORB in particular may be important candidates for further investigation in the search for the molecular basis of bipolar disorder. Positive Comment on Study
Mansour, H. A.,2009 SNP: rs10217594, rs10491929, rs17691363 Gene-based tests:X<sup>2</sup>=7.436, P-value = 0.203 in recessive model, X<sup>2</sup>=5.403, P-value = 0.475 in dominant model, X<sup>2</sup>=4.907, P-value = 0.5 in additive model in BPI. Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 26)

GO terms by PBA (count: 6)

GO terms by database search (count: 20)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 57)

Literature-origin SNPs (count: 10)

LD-proxies (count: 47)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr9:74497365..74693177 View in gBrowse
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