Gene Report

Approved Symbol	RORB
Symbol Alias	RZRB, NR1F2, ROR-BETA
Approved Name	RAR-related orphan receptor B
Location	9q22
Position	chr9:74497365-74693177, 1
External Links	HGNC: 10259 Entrez Gene: 6096 Ensembl: ENSG00000198963 UCSC: uc004ajh.3
No. of Studies	4 (Positive: 3; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Lai, Y. C., 2015	SNP: rs17611535, rs1327836, rs499922	Our results support for the involvement of RORs genes in the risk of developing BD.	Positive	Comment on Study
Byrne, E. M., 2014		P-value=0.37. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study
McGrath, C. L.,2009	SNP: rs1157358, rs3750420, rs3903529, rs7022435 Haplotype: rs11144033 - rs3903529 - rs968357(), rs17684881 - rs17612218 - rs11144020 - rs17612778 - rs17612874 - rs17691363 - rs10869430(), rs7022435 - rs17691614 - rs7032677()	We report that four intronic RORB SNPs showed positive associations with the pediatric bipolar phenotype that survived Bonferroni correction for multiple comparisons in the case-control sample.Three RORB haplotype blocks implicating an additional 11 SNPs were also associated with the disease in the case-control sample.Our findings suggest that clock genes in general and RORB in particular may be important candidates for further investigation in the search for the molecular basis of bipolar disorder.	Positive	Comment on Study
Mansour, H. A.,2009	SNP: rs10217594, rs10491929, rs17691363	Gene-based tests:X<sup>2</sup>=7.436, P-value = 0.203 in recessive model, X<sup>2</sup>=5.403, P-value = 0.475 in dominant model, X<sup>2</sup>=4.907, P-value = 0.5 in additive model in BPI. Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI.	Positive	Comment on Study

Region: chr9:74497365..74693177 View in gBrowse