Gene Report

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Basic Info

Approved Symbol	CRIM1
Previous Symbol	S52
Approved Name	cysteine rich transmembrane BMP regulator 1 (chordin-like)
Previous Name	cysteine-rich motor neuron 1
Location	2p21
Position	chr2:36355926-36551135, 1
External Links	HGNC: 2359 Entrez Gene: 51232 Ensembl: ENSG00000150938 UCSC: uc002rpd.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs2372008	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030165	PDZ domain binding	molecular function	IDA[23209302]	16
GO:0007399	nervous system development	biological process	TAS[10642437]	40
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	IEA	7
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001558	regulation of cell growth	biological process	IEA	7
GO:0010951	negative regulation of endopeptidase activity	biological process	IEA	10
GO:0048009	insulin-like growth factor receptor signaling pathway	biological process	TAS[10642437]	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005520	insulin-like growth factor binding	molecular function	IEA	2
GO:0005010	insulin-like growth factor-activated receptor activity	molecular function	TAS[10642437]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2372008	chr2:35576048 - 35576048(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p22.2-p13.3	chr2:36300000-71300000	1 (1/0/0)
2p22	chr2:31800000-41500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr2:36355926..36551135 View in gBrowse