Gene Report

Basic Info
Approved Symbol ATF4
Previous Symbol TXREB
Symbol Alias TAXREB67, CREB-2
Approved Name activating transcription factor 4
Previous Name activating transcription factor 4 (tax-responsive enhancer element B67)
Name Alias tax-responsive enhancer element B67
Location 22q13.1
Position chr22:39519695-39522685, 1
External Links HGNC: 786
Entrez Gene: 468
Ensembl: ENSG00000128272
UCSC: uc003axz.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kakiuchi, C., 2007 (b) SNP: rs1028321, rs4821907, rs6519194, rs882565
Haplotype: rs4821907 - rs1028321(), rs6519194 - rs882565(), rs6519194 - rs882565 - rs4821907(), rs6519194 - rs882565 - rs4821907 - rs1028321(G-C-C-G), rs882565 - rs4821907(), rs882565 - rs4821907 - rs1028321()
There were no significant differences in both genotype and allele frequencies in four SNPs of ATF4 locus; TDT analysis also showed no association to the illness; nominal association of ATF4 with bipolar II patients was observed, but itwas not significant after correction of multiple testing; Haplotype analysis of ATF4 in BPII patients and controls of Japanese samples showed the significant association Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 49)

GO terms by PBA (count: 4)

GO terms by database search (count: 45)

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Related other genetic factors
Gene related SNPs (count: 8)

Literature-origin SNPs (count: 4)

LD-proxies (count: 4)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr22:39519695..39522685 View in gBrowse
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