Gene Report

Approved Symbol	ST8SIA2
Previous Symbol	SIAT8B
Symbol Alias	STX, ST8SIA-II, HsT19690
Approved Name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Previous Name	sialyltransferase 8 (alpha-2, 8-sialytransferase) B
Location	15q26
Position	chr15:92393828-92468728, 1
External Links	HGNC: 10870 Entrez Gene: 8128 Ensembl: ENSG00000140557 UCSC: uc002bra.3
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McAuley, E. Z., 2012	SNP: rs11074070, rs11637898, rs2035645, rs2168351, rs3784735, rs3858917, rs4586379, rs4777974 Haplotype: rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735(A-A-G-G-A-A), rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645(T-T-A-G-T), rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735(G-C-A-A-C-C), rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645(C-C-C-C-G)	These findings suggest that variation the ST8SIA2 gene is associated with increased risk to mental illness, acting to restrict neuronal plasticity and disrupt early neuronal network formation, rendering the developing and adult brain more vulnerable to secondary genetic or environmental insults.	Positive	Comment on Study
Lee, M. T.,2011	SNP: rs7174854, rs8040009	SNPs close to ST8 a-Nacetyl- neuraminide a-2, 8-sialyltransferase (ST8SIA2) are associated with Bipolar I Disorder.	Positive	Comment on Study

Region: chr15:92393828..92468728 View in gBrowse