Gene Report

Basic Info
Approved Symbol ST8SIA2
Previous Symbol SIAT8B
Symbol Alias STX, ST8SIA-II, HsT19690
Approved Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Previous Name sialyltransferase 8 (alpha-2, 8-sialytransferase) B
Location 15q26
Position chr15:92393828-92468728, 1
External Links HGNC: 10870
Entrez Gene: 8128
Ensembl: ENSG00000140557
UCSC: uc002bra.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
McAuley, E. Z., 2012 SNP: rs11074070, rs11637898, rs2035645, rs2168351, rs3784735, rs3858917, rs4586379, rs4777974
Haplotype: rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735(A-A-G-G-A-A), rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645(T-T-A-G-T), rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735(G-C-A-A-C-C), rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645(C-C-C-C-G)
These findings suggest that variation the ST8SIA2 gene is associated with increased risk to mental illness, acting to restrict neuronal plasticity and disrupt early neuronal network formation, rendering the developing and adult brain more vulnerable to secondary genetic or environmental insults. Positive Comment on Study
Lee, M. T.,2011 SNP: rs7174854, rs8040009 SNPs close to ST8 a-Nacetyl- neuraminide a-2, 8-sialyltransferase (ST8SIA2) are associated with Bipolar I Disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 2)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 79)

Literature-origin SNPs (count: 25)

LD-proxies (count: 54)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr15:92393828..92468728 View in gBrowse
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