Gene Report

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Basic Info

Approved Symbol	ABHD2
Symbol Alias	LABH2
Approved Name	abhydrolase domain containing 2
Location	15q26.1
Position	chr15:89087459-89202360, 1
External Links	HGNC: 18717 Entrez Gene: 11057 Ensembl: ENSG00000140526 UCSC: uc002bnk.2
No. of Studies	2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs2283436	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study
Hamshere, M. L.,2009	SNP: rs16942644	the nearest gene of one independently associated SNP rs16942644 that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots)	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0052689	carboxylic ester hydrolase activity	molecular function	IEA	1
GO:0008150	biological_process	biological process	ND	24
GO:0003674	molecular_function	molecular function	ND	24
GO:0009611	response to wounding	biological process	IEA	9
GO:0030336	negative regulation of cell migration	biological process	IEA	12
GO:0008152	metabolic process	biological process	IEA	50

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2283436	chr15:89188545 - 89188545(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs16942644	chr15:89069505 - 89069505(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2238312		chr15:89190429 - 89190429(1)	intron_variant; non_coding_transcript_variant
rs13329396		chr15:89203898 - 89203898(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q26.1	chr15:88500000-93800000	1 (0/0/1)
15q25-26	chr15:78000000-101991189	1 (1/0/0)
15q26	chr15:88500000-101991189	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:89087459..89202360 View in gBrowse