Gene Report

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Basic Info

Approved Symbol	GRIA3
Previous Symbol	GLUR3
Symbol Alias	GluA3, GLURC, MRX94
Approved Name	glutamate receptor, ionotropic, AMPA 3
Previous Name	glutamate receptor, ionotrophic, AMPA 3
Location	Xq25
Position	chrX:123184153-123490915, 1
External Links	HGNC: 4573 Entrez Gene: 2892 Ensembl: ENSG00000125675 UCSC: uc033etm.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is not validated by qPCR from BD case data.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IBA	12
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0045211	postsynaptic membrane	cellular component	IBA	68

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034220	ion transmembrane transport	biological process	IBA; IEA	50
GO:0030425	dendrite	cellular component	IBA	65
GO:0007215	glutamate receptor signaling pathway	biological process	TAS[1709304]	7
GO:0035249	synaptic transmission, glutamatergic	biological process	IBA	14
GO:0006810	transport	biological process	TAS[1709304]	47
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	molecular function	IDA[21172611]	2
GO:0030054	cell junction	cellular component	IEA	88
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	cellular component	IBA; ISS	8
GO:0030666	endocytic vesicle membrane	cellular component	TAS	8
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IDA[21172611]; IEA	13

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04730	Long-term depression	15

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRIA3	PPM1G	NO	in vitro;in vivo	14663150
GRIA3	GRIP2	NO	yeast 2-hybrid	9768844
GRIA3	PICK1	YES	in vivo;yeast 2-hybrid	10027300
GRIA3	GRIA2	NO	in vitro	14687553
GRIA3	SDCBP	NO	in vitro;yeast 2-hybrid	11891216
GRIA3	GZMB	NO	in vivo	11160179
GRIA3	SQSTM1	NO	in vitro;in vivo	19004011
GRIA3	NSF	NO	yeast 2-hybrid	9697855
GRIA3	LYN	NO	in vivo	9892356

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs592807	chrX:123457805 - 123457805(1)	intron_variant	1(1/0/0)

Gene related CNVs (count: 5)

ID	Location	Size	Band	Type
CNV_Abdul Noor[2014]_39	chrX:122153999-122195582 (NCBI Build 36/hg18)	42000	Xq25	deletion
CNV_Abdul Noor[2014]_37	chrX:122153999-122195582 (NCBI Build 36/hg18)	42000	Xq25	deletion
CNV_Abdul Noor[2014]_38	chrX:122153999-122195582 (NCBI Build 36/hg18)	42000	Xq25	deletion
CNV_Abdul Noor[2014]_35	chrX:122153999-122195582 (NCBI Build 36/hg18)	42000	Xq25	deletion
CNV_Abdul Noor[2014]_36	chrX:122153999-122195582 (NCBI Build 36/hg18)	42000	Xq25	deletion

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Xq25	chrX:121800000-129500000	2 (0/1/1)
Xq24-q27.1	chrX:117400000-141200000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
18163426	658	Positive

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
22339950	Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3	Pos	GRIA3
17938633	Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t)	Pos	GRIA3

View in gBrowse

Region: chrX:123184153..123490915 View in gBrowse