Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	FOXO3
Previous Symbol	FKHRL1, FOXO3A
Symbol Alias	AF6q21, FOXO2
Approved Name	forkhead box O3
Location	6q21
Position	chr6:108559835-108684774, 1
External Links	HGNC: 3821 Entrez Gene: 2309 Ensembl: ENSG00000118689 UCSC: uc003psm.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Magno, L. A.,2011	SNP: rs1536057, rs1935952, rs2802292, rs3813498 Haplotype: rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-T-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-T-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-T-G)	These data suggest that FOXO3A is a novel susceptibility locus for BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 42)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043565	sequence-specific DNA binding	molecular function	IDA[10102273]	29
GO:0003677	DNA binding	molecular function	IDA[21329882]	83
GO:0045087	innate immune response	biological process	TAS	49
GO:0016020	membrane	cellular component	IEA	137
GO:0005634	nucleus	cellular component	IDA[10102273]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[14734530]	66

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006366	transcription from RNA polymerase II promoter	biological process	IBA	31
GO:0009653	anatomical structure morphogenesis	biological process	IBA	6
GO:0045648	positive regulation of erythrocyte differentiation	biological process	IDA[14734530]	2
GO:0034599	cellular response to oxidative stress	biological process	ISS	7
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0043525	positive regulation of neuron apoptotic process	biological process	IMP[10102273]	11
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	ISS	21
GO:0005829	cytosol	cellular component	IEA	223
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	19
GO:2000377	regulation of reactive oxygen species metabolic process	biological process	IEA	2
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IEA	2
GO:0048015	phosphatidylinositol-mediated signaling	biological process	TAS	17
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	22
GO:0005515	protein binding	molecular function	IPI[14976264]	563
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	IBA	6
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[10102273]	58
GO:0097150	neuronal stem cell maintenance	biological process	IEA	2
GO:0001221	transcription cofactor binding	molecular function	IEA	1
GO:0006417	regulation of translation	biological process	IDA[21329882]	5
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	biological process	IEA	7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[10102273]	91
GO:0030330	DNA damage response, signal transduction by p53 class mediator	biological process	IEA	1
GO:0001047	core promoter binding	molecular function	ISS	8
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IMP[18787191]	62
GO:2000177	regulation of neural precursor cell proliferation	biological process	IEA	2
GO:0042593	glucose homeostasis	biological process	IEA	19
GO:0005737	cytoplasm	cellular component	IDA[10102273]	322
GO:0001542	ovulation from ovarian follicle	biological process	IEA	3
GO:0001547	antral ovarian follicle growth	biological process	IEA	2
GO:0001544	initiation of primordial ovarian follicle growth	biological process	IEA	1
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	21
GO:0031490	chromatin DNA binding	molecular function	ISS	7
GO:0019901	protein kinase binding	molecular function	IPI[16751106]	29
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	IEA	9
GO:0001556	oocyte maturation	biological process	IEA	3

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05213	Endometrial cancer	10
hsa05223	Non-small cell lung cancer	8

Gene related BioCarta pathways (count: 4)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 4)

ID	Name	No. of Genes in BDgene
ptenPathway	PTEN dependent cell cycle arrest and apoptosis	3
aktPathway	AKT Signaling Pathway	6
longevityPathway	The IGF-1 Receptor and Longevity	6
achPathway	Role of nicotinic acetylcholine receptors in the regulation of apoptosis	6

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FOXO3	NR1H2	NO	yeast 2-hybrid	15604093
FOXO3	CHUK	NO	in vitro;in vivo	15084260
FOXO3	SGK1	NO	in vitro;in vivo	11154281
FOXO3	FOXG1	NO	in vivo	15084259
FOXO3	EP300	NO	in vitro	11896584
FOXO3	YWHAG	NO	in vivo	15324660
FOXO3	YWHAZ	NO	in vivo	10102273
FOXO3	IKBKB	NO	in vitro;in vivo	15084260
FOXO3	SMAD4	NO	in vitro;in vivo	15084259
FOXO3	NR1H3	NO	yeast 2-hybrid	15604093
FOXO3	SMAD2	NO	in vitro;in vivo	15084259
FOXO3	SMAD3	NO	in vitro;in vivo	15084259

Related other genetic factors

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1536057	chr6:108564420 - 108564420(1)	intron_variant	1(1/0/0)
rs1935952	chr6:108677702 - 108677702(1)	intron_variant	1(1/0/0)
rs2802292	chr6:108587315 - 108587315(1)	intron_variant	1(1/0/0)
rs3813498	chr6:108622962 - 108622962(1)	intron_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:108559835..108684774 View in gBrowse