Gene Report

Basic Info
Approved Symbol FOXO3
Previous Symbol FKHRL1, FOXO3A
Symbol Alias AF6q21, FOXO2
Approved Name forkhead box O3
Location 6q21
Position chr6:108559835-108684774, 1
External Links HGNC: 3821
Entrez Gene: 2309
Ensembl: ENSG00000118689
UCSC: uc003psm.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Magno, L. A.,2011 SNP: rs1536057, rs1935952, rs2802292, rs3813498
Haplotype: rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(A-G-T-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-G-T-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-C-G), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-T-C), rs1536057 - rs2802292 - rs3813498 - rs1935952(G-T-T-G)
These data suggest that FOXO3A is a novel susceptibility locus for BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 42)

GO terms by PBA (count: 6)

GO terms by database search (count: 36)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 4)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:108559835..108684774 View in gBrowse
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