Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	ZHX2
Symbol Alias	KIAA0854
Approved Name	zinc fingers and homeoboxes 2
Previous Name	zinc-fingers and homeoboxes 2
Location	8q24.13
Position	chr8:122781394-122974512, 1
External Links	HGNC: 18513 Entrez Gene: 22882 Ensembl: ENSG00000178764 UCSC: uc003ypk.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs748856, rs2833	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003714	transcription corepressor activity	molecular function	IDA[12741956]	21
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0003677	DNA binding	molecular function	IEA	83
GO:0005634	nucleus	cellular component	IDA[12741956]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[12741956]	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[12741956]	43
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0046982	protein heterodimerization activity	molecular function	IDA[12741956]	42
GO:0042802	identical protein binding	molecular function	IPI[12741956]	44
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[12741956]	62
GO:0005515	protein binding	molecular function	IPI[12741956]	563
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006402	mRNA catabolic process	biological process	IEA	2
GO:0042803	protein homodimerization activity	molecular function	IDA[12741956]	71
GO:0035019	somatic stem cell maintenance	biological process	IEA	6
GO:0045665	negative regulation of neuron differentiation	biological process	IEA	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZHX2	ZHX1	NO	in vitro;yeast 2-hybrid	12741956
ZHX2	ZHX3	NO	in vitro;in vivo;yeast 2-hybrid	14659886
ZHX2	ATXN1	YES	yeast 2-hybrid	16713569
ZHX2	NFYA	NO	in vivo;yeast 2-hybrid	12741956

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs748856	chr8:122802586 - 122802586(1)	intron_variant	1(0/0/1)
rs2833	chr8:122974409 - 122974409(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.13	chr8:121500000-126300000	1 (0/0/1)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr8:122781394..122974512 View in gBrowse