Gene Report

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Basic Info

Approved Symbol	LAMP3
Symbol Alias	LAMP, TSC403, DC-LAMP, DCLAMP, CD208
Approved Name	lysosomal-associated membrane protein 3
Location	3q26.3-q27
Position	chr3:183122213-183163839, -1
External Links	HGNC: 14582 Entrez Gene: 27074 Ensembl: ENSG00000078081 UCSC: uc003flh.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00009, Product of P truncation <=0.01=0.00004, Product of P truncation <=0.001=0.00006. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0002376	immune system process	biological process	IEA	3
GO:0097233	alveolar lamellar body membrane	cellular component	IEA	1
GO:0008283	cell proliferation	biological process	TAS[9721848]	37
GO:0005765	lysosomal membrane	cellular component	IEA	14

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs683395	chr3:183152030 - 183152030(1)	downstream_gene_variant; intron_variant	3(0/1/2)
rs514636	chr3:183152648 - 183152648(1)	downstream_gene_variant; intron_variant	1(0/0/1)
rs589445	chr3:183151207 - 183151207(1)	downstream_gene_variant; intron_variant	1(0/0/1)
rs6414498	chr3:183153426 - 183153426(1)	downstream_gene_variant; intron_variant	1(0/0/1)
rs6414500	chr3:183153511 - 183153511(1)	downstream_gene_variant; intron_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs625677	chr3:183155714 - 183155714(1)	downstream_gene_variant; intron_variant
rs501833	chr3:183160138 - 183160138(1)	intron_variant; non_coding_transcript_variant
rs682396	chr3:183152294 - 183152294(1)	downstream_gene_variant; intron_variant
rs6414499	chr3:183153460 - 183153460(1)	downstream_gene_variant; intron_variant
rs6443856	chr3:183162323 - 183162323(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q27	chr3:183000000-188200000	2 (0/0/2)
3q27-28	chr3:183000000-192600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr3:183122213..183163839 View in gBrowse