Gene Report

Basic Info
Approved Symbol ADCY8
Previous Symbol ADCY3
Symbol Alias HBAC1, AC8
Approved Name adenylate cyclase 8 (brain)
Location 8q24
Position chr8:130780301-131042426, -1
External Links HGNC: 239
Entrez Gene: 114
Ensembl: ENSG00000155897
UCSC: uc003ytd.4
No. of Studies 4 (Positive: 2; Negative: 1; trend: 1)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Zhang, P.,2010 SNP: rs1023096, rs3750889 Our association results showed suggestive evidence of association of BP with loci near ADCY8. Trend Comment on Study
de Mooij-van Malsen, A. J.,2009 After this correction the association between the ADCY8(rs3914071) and BPD remained significant (P-value = 0.0055; genetic model, without sex-stratification). Positive Comment on Study
Zandi, P. P., 2008 (b) SNP: rs1411187, rs3750889
Haplotype: rs1411187 - rs6986303()
None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. Positive Comment on Study
McDonald, M. L.,2012 SNP: rs2228950 None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08). Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 27)

GO terms by PBA (count: 5)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 4)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 38)

Literature-origin SNPs (count: 4)

LD-proxies (count: 34)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr8:130780301..131042426 View in gBrowse
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