Gene Report

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Basic Info

Approved Symbol	CNR2
Symbol Alias	CB2
Approved Name	cannabinoid receptor 2 (macrophage)
Location	1p
Position	chr1:23870526-23913362, -1
External Links	HGNC: 2160 Entrez Gene: 1269 Ensembl: ENSG00000188822 UCSC: uc001bif.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Minocci, D.,2011	SNP: rs2229579, rs2501432, rs41311993	Though further investigations are necessary to confirm this data, our results suggest that CB2 cannabinoid receptor may play a role in BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	TAS[8679694]	158
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0006954	inflammatory response	biological process	IEA	23

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019233	sensory perception of pain	biological process	IEA	15
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8679694]	17
GO:0043204	perikaryon	cellular component	IEA	17
GO:0050728	negative regulation of inflammatory response	biological process	IEA	6
GO:0032496	response to lipopolysaccharide	biological process	IEA	22
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	cellular component	IEA	6
GO:0051001	negative regulation of nitric-oxide synthase activity	biological process	IEA	2
GO:0038171	cannabinoid signaling pathway	biological process	IEA; TAS[8679694]	2
GO:0033004	negative regulation of mast cell activation	biological process	IEA	2
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0045759	negative regulation of action potential	biological process	IEA	3
GO:0030425	dendrite	cellular component	IEA	65
GO:0032229	negative regulation of synaptic transmission, GABAergic	biological process	IEA	2
GO:0004949	cannabinoid receptor activity	molecular function	IEA	2
GO:0006955	immune response	biological process	TAS[7556170]	19

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CNR2	GNA15	NO	in vivo	12095632

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs41311993	chr1:23875221 - 23875221(1)	missense_variant	1(1/0/0)
rs2229579	chr1:23874672 - 23874672(1)	missense_variant	1(0/1/0)
rs2501432	chr1:23875430 - 23875430(1)	missense_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs3003329		chr1:23867385 - 23867385(1)	downstream_gene_variant; intron_variant
rs2070953		chr1:23868372 - 23868372(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p35-p36	chr1:0-34300000	1 (1/0/0)
1p33-p36	chr1:0-50200000	1 (0/0/1)
1p36	chr1:0-27600000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
17353912	Selected differentially expressed genes in hippocampus	Pos	CNR2

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Region: chr1:23870526..23913362 View in gBrowse