Gene Report

Basic Info
Approved Symbol FOXP2
Previous Symbol TNRC10, SPCH1
Symbol Alias CAGH44
Approved Name forkhead box P2
Name Alias trinucleotide repeat containing 10, "forkhead/winged-helix transcription factor", "speech and language disorder 1", "CAG repeat protein 44"
Location 7q31
Position chr7:114086327-114693772, 1
External Links HGNC: 13875
Entrez Gene: 93986
Ensembl: ENSG00000128573
UCSC: uc003vgz.3
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Li, T.,2013 SNP: rs1358278, rs923875, rs6466488, rs17137124, rs1563408, rs2189015, rs2396753, rs6960610, rs10447760, rs9969232, rs1456029, rs10250103 None of the 12 SNPs in FoxP2 was signifi cant in bipolar disorder. Negative Comment on Study
Xu, W., 2014 SNP: rs11771168 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 27)

GO terms by PBA (count: 4)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 87)

Literature-origin SNPs (count: 13)

LD-proxies (count: 74)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr7:114086327..114693772 View in gBrowse
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