Gene Report

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Basic Info

Approved Symbol	TRIO
Symbol Alias	ARHGEF23
Approved Name	trio Rho guanine nucleotide exchange factor
Previous Name	triple functional domain (PTPRF interacting)
Location	5p14-p15.1
Position	chr5:14143702-14532128, 1
External Links	HGNC: 12303 Entrez Gene: 7204 Ensembl: ENSG00000038382 UCSC: uc003jff.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs16903467	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005085	guanyl-nucleotide exchange factor activity	molecular function	TAS[8643598]	3
GO:0004674	protein serine/threonine kinase activity	molecular function	IEA	27
GO:0007411	axon guidance	biological process	TAS	60
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA	7

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9
GO:0043065	positive regulation of apoptotic process	biological process	TAS	25
GO:0005524	ATP binding	molecular function	IEA	118
GO:0097190	apoptotic signaling pathway	biological process	TAS	13
GO:0043547	positive regulation of GTPase activity	biological process	IEA; TAS[8643598]	30
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0005515	protein binding	molecular function	IPI[17043677]	563
GO:0019899	enzyme binding	molecular function	IEA	34
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0005829	cytosol	cellular component	TAS	223
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	biological process	TAS[8643598]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
rac1Pathway	Rac 1 cell motility signaling pathway	6

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRIO	FLNA	NO	in vitro;yeast 2-hybrid	11146652
TRIO	RHOA	NO	in vitro	10948190
TRIO	PTK2	NO	in vitro;in vivo	12551902
TRIO	BLMH	YES	yeast 2-hybrid	16169070
TRIO	PTPRF	NO	in vitro;in vivo	8643598

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs16903467	chr5:14395369 - 14395369(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5pter-p15.1	chr5:0-18400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
15303102	Genes altered in major depressive disorder	Pos	TRIO

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Region: chr5:14143702..14532128 View in gBrowse