Gene Report

Basic Info
Approved Symbol PER3
Approved Name period circadian clock 3
Previous Name period (Drosophila) homolog 3, "period homolog 3 (Drosophila)"
Location 1p36.23
Position chr1:7784320-7845177, 1
External Links HGNC: 8847
Entrez Gene: 8863
Ensembl: ENSG00000049246
UCSC: uc001aoo.4
No. of Studies 7 (Positive: 3; Negative: 4; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 7)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Mansour, H. A., 2006 SNP: rs10462018, rs10462020, rs10462021, rs228729, rs2859387, rs4908699 No significant association was detected in any sample using any test. Negative Comment on Study
Nievergelt, C. M., 2006 Haplotype: rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(T-C-C-A-4), rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-C-C-G-4), rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-T-C-A-5), rs228666 - rs228696 - rs2859388 - rs11576985(C-C-A-4), rs228666 - rs228696 - rs2859388 - rs11576985(C-C-G-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-T-C-C-A-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-C-C-C-G-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(T-C-T-C-A-5) Single SNP TDT analyses showed no evidence for association to BPAD. Haplotypes in ARNTL and PER3 were found to be significantly associated with BPAD via single-gene permutation tests. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.14. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Yosifova, A.,2009 SNP: rs228642, rs228666, rs228697, rs228729, rs2859388 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Soria, V.,2010 SNP: rs11121029, rs228642 Significant associations of PER3 gene were found in BPD patients. Positive Comment on Study
Dmitrzak-Weglarz, M. P., 2014 We established significant epistatic interaction between PER3 (rs2172563) and ARNTL(rs4146388 and rs7107287) in case of BPD. Positive Comment on Study
Mansour, H. A.,2009 SNP: rs10462021, rs2640909 Gene-based tests:X<sup>2</sup>=3.663, P-value = 0.487 in recessive model, X<sup>2</sup>=2.145, P-value = 0.784 in dominant model, X<sup>2</sup>=1.5, P-value = 0.847 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 11)

GO terms by PBA (count: 2)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 52)

Literature-origin SNPs (count: 12)

LD-proxies (count: 40)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr1:7784320..7845177 View in gBrowse
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