Gene Report

Approved Symbol	PER3
Approved Name	period circadian clock 3
Previous Name	period (Drosophila) homolog 3, "period homolog 3 (Drosophila)"
Location	1p36.23
Position	chr1:7784320-7845177, 1
External Links	HGNC: 8847 Entrez Gene: 8863 Ensembl: ENSG00000049246 UCSC: uc001aoo.4
No. of Studies	7 (Positive: 3; Negative: 4; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Mansour, H. A., 2006	SNP: rs10462018, rs10462020, rs10462021, rs228729, rs2859387, rs4908699	No significant association was detected in any sample using any test.	Negative	Comment on Study
Nievergelt, C. M., 2006	Haplotype: rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(T-C-C-A-4), rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-C-C-G-4), rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-T-C-A-5), rs228666 - rs228696 - rs2859388 - rs11576985(C-C-A-4), rs228666 - rs228696 - rs2859388 - rs11576985(C-C-G-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-T-C-C-A-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(C-C-C-C-G-4), rs228729 - rs228642 - rs228666 - rs228696 - rs2859388 - rs11576985(T-C-T-C-A-5)	Single SNP TDT analyses showed no evidence for association to BPAD. Haplotypes in ARNTL and PER3 were found to be significantly associated with BPAD via single-gene permutation tests.	Positive	Comment on Study
Byrne, E. M., 2014		P-value=0.14. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study
Yosifova, A.,2009	SNP: rs228642, rs228666, rs228697, rs228729, rs2859388	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Soria, V.,2010	SNP: rs11121029, rs228642	Significant associations of PER3 gene were found in BPD patients.	Positive	Comment on Study
Dmitrzak-Weglarz, M. P., 2014		We established significant epistatic interaction between PER3 (rs2172563) and ARNTL(rs4146388 and rs7107287) in case of BPD.	Positive	Comment on Study
Mansour, H. A.,2009	SNP: rs10462021, rs2640909	Gene-based tests:X<sup>2</sup>=3.663, P-value = 0.487 in recessive model, X<sup>2</sup>=2.145, P-value = 0.784 in dominant model, X<sup>2</sup>=1.5, P-value = 0.847 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study

Region: chr1:7784320..7845177 View in gBrowse