Gene Report

Basic Info
Approved Symbol BCR
Previous Symbol D22S11, BCR1
Symbol Alias D22S662, CML, PHL, ALL
Approved Name breakpoint cluster region
Location 22q11
Position chr22:23179704-23318037, 1
External Links HGNC: 1014
Entrez Gene: 613
Ensembl: ENSG00000186716
UCSC: uc002zww.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs131690, rs131702, rs140504, rs2156921, rs2213172, rs2267013, rs2267015, rs2267020, rs3761418 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Hashimoto, R.,2005(a) SNP: rs131690, rs131702, rs140504, rs1811017, rs2156921, rs2213172, rs2267012, rs2267013, rs2267015, rs2267020, rs3761418
Haplotype: rs1811017 - rs140504 - rs131690 - rs131702(A-A-A-T), rs1811017 - rs140504 - rs131690 - rs131702(A-G-G-G)
Our results suggest that genetic variations in the BCR gene could confer susceptibility to bipolar disorder and major depressive disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 33)

GO terms by PBA (count: 5)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 33)

Related other genetic factors
Gene related SNPs (count: 76)

Literature-origin SNPs (count: 11)

LD-proxies (count: 65)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr22:23179704..23318037 View in gBrowse
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