Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	CMKLR1
Symbol Alias	RVER1
Approved Name	chemokine-like receptor 1
Name Alias	resolvin E1 receptor, "chemerin receptor"
Location	12q23.3
Position	chr12:108288044-108339341, -1
External Links	HGNC: 2121 Entrez Gene: 1240 Ensembl: ENSG00000174600 UCSC: uc009zuw.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs17040430	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	NAS[9603476]	219
GO:0004872	receptor activity	molecular function	TAS[9144535]	19
GO:0005886	plasma membrane	cellular component	IDA[14530373]	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[9425281]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050848	regulation of calcium-mediated signaling	biological process	IDA[14530373]	2
GO:0006935	chemotaxis	biological process	IDA[14530373]	7
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IDA[15753205]	6
GO:0045600	positive regulation of fat cell differentiation	biological process	ISS	9
GO:0010759	positive regulation of macrophage chemotaxis	biological process	IMP[19443732]	2
GO:0006955	immune response	biological process	TAS[9425281]	19
GO:0032695	negative regulation of interleukin-12 production	biological process	ISS	3
GO:0005515	protein binding	molecular function	IPI[14530373]	563
GO:0070098	chemokine-mediated signaling pathway	biological process	IEA; TAS[9425281]	3
GO:0001501	skeletal system development	biological process	TAS[9144535]	16
GO:0004950	chemokine receptor activity	molecular function	IEA	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[14530373]; NAS[9603476]	64
GO:0004930	G-protein coupled receptor activity	molecular function	NAS[9603476]	26

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CMKLR1	TPST1	NO	in vitro	17558413
CMKLR1	TPST2	YES	in vitro	17558413

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17040430	chr12:108349043 - 108349043(1)		1(0/1/0)

rs_ID	Location	Functional Annotation
rs7314414	chr12:108325233 - 108325233(1)	intron_variant; upstream_gene_variant
rs1399822	chr12:108319004 - 108319004(1)	intron_variant; upstream_gene_variant
rs7304432	chr12:108342777 - 108342777(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q23	chr12:95800000-108600000	2 (0/1/1)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr12:108288044..108339341 View in gBrowse