BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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GO Report

Basic Info

ID	GO:0005216
Name	ion channel activity
Type	molecular function
No. of Genes in BDgene	2
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
GO: 0005216: ion channel act.	PBA paper	Askland, K.,2009	WTCCC Frequentist genotypic	Fisher's exact test	P < 0.05 from the WTCCC PBAs
GO: 0005216: ion channel act.	PBA paper	Askland, K.,2009	WTCCC Bayesian genotypic	Fisher's exact test	P < 0.05 from the WTCCC PBAs
GO: 0005216: ion channel act.	PBA paper	Askland, K.,2009	NIMH	Fisher's exact test	Results given for gene sets with P < 0.05 from the NIMH PBA; Molecular function
ION CHANNEL ACTIVITY	i-GSEA analysis	Smith, E. N., Mol Psychiatry, 2009	dbGaP GAIN EA	i-GSEA by using i-GSEA4GWAS	P-value< 0.001, FDR=0.013428571	Link in i-GSEA4GWAS

GO related genes in BDgene (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	2q31.1	2(0/1/1)	TAS[6688857]
HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11q23.1	2(1/1/0)	TAS[9950429]