Gene Report

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Basic Info

Approved Symbol	RGMA
Symbol Alias	RGM, RGMa
Approved Name	repulsive guidance molecule family member a
Previous Name	RGM domain family, member A
Location	15q26.1
Position	chr15:93035273-93089204, -1
External Links	HGNC: 30308 Entrez Gene: 56963 Ensembl: ENSG00000182175 UCSC: uc010urc.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McAuley, E. Z., 2012	SNP: rs4777760	Nominally significant association (P < 0.05) was found with 1 SNP with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	TAS	60
GO:0005886	plasma membrane	cellular component	IBA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030509	BMP signaling pathway	biological process	IBA	6
GO:0005783	endoplasmic reticulum	cellular component	IDA	49
GO:0031225	anchored component of membrane	cellular component	IEA	11
GO:0015026	coreceptor activity	molecular function	IBA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RGMA	SGSM2	NO	yeast 2-hybrid	16169070
RGMA	PPP1R16A	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4777760	chr15:93059088 - 93059088(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q26.1	chr15:88500000-93800000	1 (0/0/1)
15q25-26	chr15:78000000-101991189	1 (1/0/0)
15q26	chr15:88500000-101991189	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22693595	No significant association was reported in this study.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
18367154	LD mapping showed nominally significant association in NTRK3, FLJ12484, RHCG, DKFZp547K1113, VPS33B, SV2B, SLCO3A1, RGMA, and MCTP2 with MDD-RE	Pos	RGMA

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Region: chr15:93035273..93089204 View in gBrowse