Gene Report

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Basic Info

Approved Symbol	GPR87
Previous Symbol	GPR95
Approved Name	G protein-coupled receptor 87
Location	3q24
Position	chr3:151294086-151316952, -1
External Links	HGNC: 4538 Entrez Gene: 53836 Ensembl: ENSG00000138271 UCSC: uc003eyt.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IBA	158
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IEA	11

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045028	G-protein coupled purinergic nucleotide receptor activity	molecular function	IBA	2
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IBA	64
GO:0008150	biological_process	biological process	ND	24
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	biological process	IBA; IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_3	chr3:152495187-152534813 (NCBI Build 36/hg18)	40000	3q25.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q22.1-q25.31	chr3:129500000-157300000	1 (0/1/0)
3q25	chr3:149200000-161000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr3:151294086..151316952 View in gBrowse