Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	STK24
Symbol Alias	MST-3, MST3, MST3B, STK3, STE20
Approved Name	serine/threonine kinase 24
Previous Name	serine/threonine kinase 24 (Ste20, yeast homolog)
Name Alias	STE20-like kinase 3, "sterile 20-like kinase 3"
Location	13q31.2-q32.3
Position	chr13:98445185-98577940, -1
External Links	HGNC: 11403 Entrez Gene: 8428 Ensembl: ENSG00000102572 UCSC: uc001vnn.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0011. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs3783006, rs7324994, rs9517312, rs9517313, rs9517328, rs9556964	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[16314523]	27
GO:0016020	membrane	cellular component	IEA	137
GO:0005634	nucleus	cellular component	IDA[12107159]	283
GO:0004672	protein kinase activity	molecular function	TAS[9353338]	13

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0023014	signal transduction by phosphorylation	biological process	IBA	5
GO:0030336	negative regulation of cell migration	biological process	IMP[17046825]	12
GO:0006915	apoptotic process	biological process	TAS	39
GO:0006468	protein phosphorylation	biological process	IDA[19604147]	42
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0004702	receptor signaling protein serine/threonine kinase activity	molecular function	IBA	5
GO:0048679	regulation of axon regeneration	biological process	IMP[19855390]	1
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	TAS	3
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005829	cytosol	cellular component	TAS	223
GO:0005730	nucleolus	cellular component	IDA	28
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0042542	response to hydrogen peroxide	biological process	IDA[22291017]	4
GO:0046777	protein autophosphorylation	biological process	IDA[17046825]	16
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0097194	execution phase of apoptosis	biological process	IMP[12107159]	3
GO:0007165	signal transduction	biological process	TAS[9353338]	136
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	biological process	IMP[19604147]	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
STK24	CASP7	NO	in vitro;in vivo	12107159
STK24	CASP3	NO	in vivo	12107159
STK24	PDCD10	NO	yeast 2-hybrid	16189514
STK24	STK38L	YES	in vitro;in vivo	16314523
STK24	CASP8	NO	in vitro;in vivo	12107159

Related other genetic factors

Gene related SNPs (count: 24)

Literature-origin SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3783006	chr13:98458955 - 98458955(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs9517313	chr13:98453638 - 98453638(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)
rs7324994	chr13:98525709 - 98525709(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs9556964	chr13:98507052 - 98507052(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9517328	chr13:98503293 - 98503293(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9517312	chr13:98451601 - 98451601(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

LD-proxies (count: 18)

rs_ID	Location	Functional Annotation
rs9300485	chr13:98525137 - 98525137(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3901153	chr13:98517232 - 98517232(1)	intron_variant; non_coding_transcript_variant
rs9513439	chr13:98517754 - 98517754(1)	intron_variant; non_coding_transcript_variant
rs9513436	chr13:98513851 - 98513851(1)	intron_variant; non_coding_transcript_variant
rs4772087	chr13:98462787 - 98462787(1)	intron_variant
rs9517335	chr13:98516096 - 98516096(1)	intron_variant; non_coding_transcript_variant
rs9517327	chr13:98502081 - 98502081(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs9300483	chr13:98512883 - 98512883(1)	intron_variant; non_coding_transcript_variant
rs7323291	chr13:98486281 - 98486281(1)	intron_variant; non_coding_transcript_variant
rs9517325	chr13:98491925 - 98491925(1)	intron_variant; non_coding_transcript_variant
rs12871067	chr13:98484813 - 98484813(1)	intron_variant; non_coding_transcript_variant
rs9513431	chr13:98482372 - 98482372(1)	intron_variant; non_coding_transcript_variant
rs2274055	chr13:98475242 - 98475242(1)	intron_variant; non_coding_transcript_variant; splice_region_variant
rs9513435	chr13:98508080 - 98508080(1)	intron_variant; non_coding_transcript_variant
rs6956	chr13:98452435 - 98452435(1)	3_prime_UTR_variant; downstream_gene_variant
rs3742134	chr13:98451916 - 98451916(1)	3_prime_UTR_variant; downstream_gene_variant
rs4772092	chr13:98514360 - 98514360(1)	intron_variant; non_coding_transcript_variant
rs4529985	chr13:98514866 - 98514866(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q32.2	chr13:97500000-98700000	1 (0/0/1)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
15364420	298	Negative

Gene relationship with MDD

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Region: chr13:98445185..98577940 View in gBrowse