Gene Report

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Basic Info

Approved Symbol	MEOX2
Previous Symbol	GAX
Symbol Alias	MOX2
Approved Name	mesenchyme homeobox 2
Previous Name	mesenchyme homeo box 2 (growth arrest-specific homeo box), "mesenchyme homeobox 2 (growth arrest-specific homeo box)"
Name Alias	growth arrest-specific homeobox
Location	7p22.1-p21.3
Position	chr7:15611212-15686812, -1
External Links	HGNC: 7014 Entrez Gene: 4223 Ensembl: ENSG00000106511 UCSC: uc003stc.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		MEOX2 microRNA was down-regulated in depressed suicide individuals.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[22206000]	66
GO:0005634	nucleus	cellular component	IDA[22206000]	283
GO:0007275	multicellular organismal development	biological process	TAS[7713505]	24
GO:0043565	sequence-specific DNA binding	molecular function	IDA[9073066]; IMP[22206000]	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[16335786]	322
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[17074759]	23
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular function	IDA[17074759]	5
GO:0007519	skeletal muscle tissue development	biological process	IEA	6
GO:0060173	limb development	biological process	IEA	1
GO:0001757	somite specification	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[16335786]	563
GO:0016607	nuclear speck	cellular component	IEA	16
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IDA[17074759]; IMP[17074759]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[17074759]; IMP[17074759]	91
GO:0001525	angiogenesis	biological process	IEA	20
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0060021	palate development	biological process	IEA	6
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IDA[17074759]; IMP[17074759]	18
GO:0008015	blood circulation	biological process	TAS[7713505]	6
GO:0070997	neuron death	biological process	IMP[22166940]	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MEOX2	VIP	YES	yeast 2-hybrid	16189514
MEOX2	HSPA2	YES	yeast 2-hybrid	16713569
MEOX2	TULP2	NO	yeast 2-hybrid	16189514
MEOX2	PAX3	NO	in vitro;yeast 2-hybrid	11423130
MEOX2	KRTAP4-12	NO	yeast 2-hybrid	16189514
MEOX2	RND2	NO	yeast 2-hybrid	16189514
MEOX2	SAMM50	NO	yeast 2-hybrid	16189514
MEOX2	PAX1	NO	in vitro;yeast 2-hybrid	11423130

Related other genetic factors

Gene related SNPs (count: 21)

rs_ID	Location	Functional Annotation
rs10228856	chr7:15649222 - 15649222(1)	intron_variant
rs3801421	chr7:15646548 - 15646548(1)	intron_variant
rs12056299	chr7:15656526 - 15656526(1)	intron_variant
rs2389538	chr7:15655212 - 15655212(1)	intron_variant
rs12666514	chr7:15631700 - 15631700(1)	intron_variant
rs7786092	chr7:15627906 - 15627906(1)	intron_variant
rs978993	chr7:15636010 - 15636010(1)	intron_variant
rs3801419	chr7:15635944 - 15635944(1)	intron_variant
rs6970492	chr7:15615540 - 15615540(1)	intron_variant
rs981597	chr7:15659190 - 15659190(1)	intron_variant
rs917437	chr7:15657051 - 15657051(1)	intron_variant
rs6969225	chr7:15661242 - 15661242(1)	intron_variant
rs6972599	chr7:15665230 - 15665230(1)	intron_variant; upstream_gene_variant
rs758297	chr7:15667820 - 15667820(1)	intron_variant; upstream_gene_variant
rs10275641	chr7:15616371 - 15616371(1)	intron_variant
rs6953784	chr7:15628445 - 15628445(1)	intron_variant
rs7786884	chr7:15658465 - 15658465(1)	intron_variant
rs10282109	chr7:15660191 - 15660191(1)	intron_variant
rs10224510	chr7:15617903 - 15617903(1)	intron_variant
rs2282932	chr7:15625461 - 15625461(1)	intron_variant
rs10777	chr7:15611533 - 15611533(1)	3_prime_UTR_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:15611212..15686812 View in gBrowse