Gene Report

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Basic Info

Approved Symbol	TRH
Approved Name	thyrotropin-releasing hormone
Name Alias	prothyroliberin
Location	3q13.3-q21
Position	chr3:129974305-129977938, 1
External Links	HGNC: 12298 Entrez Gene: 7200 Ensembl: ENSG00000170893 UCSC: uc003enc.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs7645772	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030141	secretory granule	cellular component	IEA	14
GO:0042755	eating behavior	biological process	IEA	5
GO:0009409	response to cold	biological process	IEA	7
GO:0009749	response to glucose	biological process	IEA	8
GO:0009755	hormone-mediated signaling pathway	biological process	IEA	5
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0045471	response to ethanol	biological process	IEA	24
GO:0032024	positive regulation of insulin secretion	biological process	IEA	7
GO:0008437	thyrotropin-releasing hormone activity	molecular function	IEA	1
GO:0005184	neuropeptide hormone activity	molecular function	IEA	8
GO:0014050	negative regulation of glutamate secretion	biological process	IEA	4
GO:0007267	cell-cell signaling	biological process	TAS[2126343]	29
GO:0007165	signal transduction	biological process	TAS[2126343]	136
GO:0051412	response to corticosterone	biological process	IEA	9
GO:0001692	histamine metabolic process	biological process	IEA	1
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	biological process	IEA	3
GO:2000252	negative regulation of feeding behavior	biological process	IEA	3
GO:0005576	extracellular region	cellular component	TAS	97
GO:0007628	adult walking behavior	biological process	IEA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRH	CPE	NO	in vivo	12270926

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7645772	chr3:129976530 - 129976530(1)	intron_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs13091203		chr3:129973831 - 129973831(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q22.1-q25.31	chr3:129500000-157300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:129974305..129977938 View in gBrowse