Gene Report

Approved Symbol	PREP
Approved Name	prolyl endopeptidase
Location	6q22
Position	chr6:105277565-105403084, -1
External Links	HGNC: 9358 Entrez Gene: 5550 Ensembl: ENSG00000085377 UCSC: uc003prc.3
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs1190053, rs12213914	For gene-based test, P-value = 0.22 in STEP1; P-value = 0.0089 in NIMH; P-value = 0.014 in STEP1 and NIMH. nominally significant in NIMH sample and pooled sample, but not survive Bonferroni correction test.	Positive	Comment on Study
Mamdani, F., 2007	SNP: rs1028792, rs1149320, rs12192054, rs3799990, rs3818281, rs6902415, rs720225, rs9486069, rs9500087	The findings do not support the hypothesis that genetic variation in PREP gene plays a major role in the etiology of BD or Li response, although PREP6 GG genotype was significantly associated with BD	Positive	Comment on Study

Region: chr6:105277565..105403084 View in gBrowse