Gene Report

Basic Info
Approved Symbol PREP
Approved Name prolyl endopeptidase
Location 6q22
Position chr6:105277565-105403084, -1
External Links HGNC: 9358
Entrez Gene: 5550
Ensembl: ENSG00000085377
UCSC: uc003prc.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fan, J., 2010 SNP: rs1190053, rs12213914 For gene-based test, P-value = 0.22 in STEP1; P-value = 0.0089 in NIMH; P-value = 0.014 in STEP1 and NIMH. nominally significant in NIMH sample and pooled sample, but not survive Bonferroni correction test. Positive Comment on Study
Mamdani, F., 2007 SNP: rs1028792, rs1149320, rs12192054, rs3799990, rs3818281, rs6902415, rs720225, rs9486069, rs9500087 The findings do not support the hypothesis that genetic variation in PREP gene plays a major role in the etiology of BD or Li response, although PREP6 GG genotype was significantly associated with BD Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 8)

GO terms by PBA (count: 2)

GO terms by database search (count: 6)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 46)

Literature-origin SNPs (count: 11)

LD-proxies (count: 35)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:105277565..105403084 View in gBrowse
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