Gene Report

Basic Info
Approved Symbol SNAP25
Previous Symbol SNAP
Symbol Alias SNAP-25, RIC-4, RIC4, SEC9, bA416N4.2, dJ1068F16.2
Approved Name synaptosomal-associated protein, 25kDa
Previous Name synaptosomal-associated protein, 25kD
Name Alias resistance to inhibitors of cholinesterase 4 homolog
Location 20p12-p11.2
Position chr20:10218830-10307418, 1
External Links HGNC: 11132
Entrez Gene: 6616
Ensembl: ENSG00000132639
UCSC: uc002wnr.2
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hattori, E.,2009 SNP: rs1158497 After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. Positive Comment on Study
Etain, B., 2010 SNP: rs1051312, rs2076239, rs362987, rs363006, rs6039769, rs8636
Haplotype: rs2076239 - rs362987 - rs363006 - rs1051312(ACAC), rs362987 - rs363006 - rs1051312 - rs8636(CACC), rs6039769 - rs2076239 - rs362987 - rs363006(AAAG), SNAP25_promoter_SNP1 - rs6039769 - rs2076239 - rs362987(GAAA)
Other variant: SNAP25_promoter_SNP1
one variant, located in the promoter region of SNAP25, was associated with early-onset BD but not with the late-onset subgroup. Individuals homozygous for this variant showed a significant higher SNAP25b expression level in prefrontal cortex. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 32)

GO terms by PBA (count: 3)

GO terms by database search (count: 29)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 24)

Related other genetic factors
Gene related SNPs (count: 43)

Literature-origin SNPs (count: 7)

LD-proxies (count: 36)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr20:10218830..10307418 View in gBrowse
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