Gene Report

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Basic Info

Approved Symbol	GSC2
Previous Symbol	GSCL
Approved Name	goosecoid homeobox 2
Previous Name	goosecoid-like
Location	22q11.21
Position	chr22:19148576-19150283, -1
External Links	HGNC: 4613 Entrez Gene: 2928 Ensembl: ENSG00000063515 UCSC: uc011ags.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[9700206]	66
GO:0003677	DNA binding	molecular function	TAS[9441739]	83
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0009653	anatomical structure morphogenesis	biological process	TAS[9150167]	6
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[9700206]	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_306	chr22:17386126-18691917 (Affymetrix SNP 6.0 array reference genome)	1305791		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
22q11.2	chr22:17400000-25500000	2 (0/2/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
11891283	432	Negative
16380905	432	Negative

Gene relationship with MDD

View in gBrowse

Region: chr22:19148576..19150283 View in gBrowse