Gene Report

Basic Info
Approved Symbol HTR6
Symbol Alias 5-HT6, 5-HT6R
Approved Name 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Previous Name 5-hydroxytryptamine (serotonin) receptor 6
Location 1p36-p35
Position chr1:19665287-19679562, 1
External Links HGNC: 5301
Entrez Gene: 3362
Ensembl: ENSG00000158748
UCSC: uc001bcl.4
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hong, C. J.,1999 Other variant: HTR6_267C/T The results demonstrated that there were no significant differences in genotype or allele frequencies between controls and all patients, or between controls and patients with bipolar disorders or major depression, separately. Negative Comment on Study
Vogt, I. R.,2000 Other variant: HTR6_126G/T, HTR6_873+30C/T, HTR6_267C/T, HTR6_873+128A/C Our preliminary data suggest that bipolar affective disorder may be associated with variation in the 5-HT(6) gene. Positive Comment on Study
Fukuo, Y.,2010 SNP: rs1805054, rs3790757, rs4912138, rs6693503, rs9659997
Haplotype: rs1805054 - rs4912138(), rs1805054 - rs4912138 - rs3790757(), rs1805054 - rs4912138 - rs3790757 - rs9659997(), rs3790757 - rs9659997(), rs4912138 - rs3790757(), rs4912138 - rs3790757 - rs9659997(), rs6693503 - rs1805054(), rs6693503 - rs1805054 - rs4912138(), rs6693503 - rs1805054 - rs4912138 - rs3790757(), rs6693503 - rs1805054 - rs4912138 - rs3790757 - rs9659997()
In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 21)

GO terms by PBA (count: 3)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 16)

Literature-origin SNPs (count: 5)

LD-proxies (count: 11)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 6)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr1:19665287..19679562 View in gBrowse
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