Gene Report

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Basic Info

Approved Symbol	HOXA3
Previous Symbol	HOX1E, HOX1
Approved Name	homeobox A3
Previous Name	homeo box A3
Location	7p15.2
Position	chr7:27106184-27152581, -1
External Links	HGNC: 5104 Entrez Gene: 3200 Ensembl: ENSG00000105997 UCSC: uc011jzl.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00034, Product of P truncation <=0.01=0.00034, Product of P truncation <=0.001=0.00034. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[21516116]	563
GO:0048704	embryonic skeletal system morphogenesis	biological process	IEA	3
GO:0048538	thymus development	biological process	IEA	5
GO:0051216	cartilage development	biological process	IEA	6
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0071837	HMG box domain binding	molecular function	IEA	2
GO:0009952	anterior/posterior pattern specification	biological process	IEA	6
GO:0001974	blood vessel remodeling	biological process	IEA	8
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0060017	parathyroid gland development	biological process	IEA	1
GO:0010159	specification of organ position	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	44
GO:0021615	glossopharyngeal nerve morphogenesis	biological process	IEA	1
GO:0030878	thyroid gland development	biological process	IEA	3
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0001525	angiogenesis	biological process	IEP[17972163]	20
GO:0048645	organ formation	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HOXA3	SOX10	NO	yeast 2-hybrid	16582099

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr7:27106184..27152581 View in gBrowse