BDgene

BD & SZ shared SNPs from cross-disorder studies

Total result: 838

SNP Related Gene(s) No. of Studies (Positive/Trend/Negative) for BD No. of Studies for SZ Overlap with SZ
Statistical Results Description Result Category Reference
rs2391191 DAOA DAOA-AS1 18(3/0/15) 7
Association analysis:allele P-value = 0.037, OR=1.28, genot...... Association analysis:allele P-value = 0.037, OR=1.28, genotype P-value = 0.108, OR=1.41 More... Significant associations were found in SZ patients. Significant associations were found in SZ patients. Positive Schumacher, J.,2004
Meta analysis:Fixed-effects model:ORA = 1.03, 95% CI: 1.00-...... Meta analysis:Fixed-effects model:ORA = 1.03, 95% CI: 1.00-1.07, p = 0.07;Random-effects model: ORA = 1.05, 95% CI:0.97-1.13, p = 0.22.But in the East Asian subgroup (p = 0.02). More... Significant association was observed in the East Asian subg...... Significant association was observed in the East Asian subgroup. More... Positive Muller, D. J.,2011
rs6265 BDNF BDNF-AS 17(7/0/10) 3
allele:X2=7.89, P-value = 0.0049, OR=1.48, upper...... allele:X2=7.89, P-value = 0.0049, OR=1.48, upper 95%CI=1.95, lower CI=1.13;genotype:X2=10.1; P-value = 0.0015; OR=1.68; upper 95% CI=1.22, lower 95% CI=2.32. More... Significant association was observed in SZ. Significant association was observed in SZ. Positive Neves-Pereira, M.,2005
P-value = 0.944, OR=1.00 (95% CI: 0.89-1.11), z=0.07, heter...... P-value = 0.944, OR=1.00 (95% CI: 0.89-1.11), z=0.07, heterogeneity P-value = 0.078, X2=19.47 (d.f.=12) for schizophrenia More... The meta-analysis of data showed no support for an associat...... The meta-analysis of data showed no support for an association with the putative risk allele (Met). Some evidence of heterogeneity was observed among the studies, but this did not attain statistical significance. More... Negative Kanazawa, T., 2007
rs1006737 CACNA1C 15(9/2/4) 4
Conditional FDR; SCZ loci given BD: P-value=0.0000352, FDR=...... Conditional FDR; SCZ loci given BD: P-value=0.0000352, FDR=0.104, FDR=0.022 for SCZ and BD||Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.022 for BD and SZ, Z-score=4.137 for SZ More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.61. This SNP is with conjunction FDR<0.13 with schizophrenia and bipolar disorder considered jointly. More... Positive Andreassen OA, 2013
genotype test P-value = 0.034 when using Controls (WTCCC) a...... genotype test P-value = 0.034 when using Controls (WTCCC) as control, genotype test P-value = 0.043 when using WTCCC expanded reference as control, OR(%95 CI) =1.15 (0.99-1.32) for allele test when using Controls (WTCCC) as control, OR(%95 CI)=1.13 (0.98-1.29) for allele test when using WTCCC expanded reference as control; More... We found that the risk allele conferred increased risk for ...... We found that the risk allele conferred increased risk for schizophrenia (P= 0.034) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15). More... Positive Green, E. K., 2010
rs1935062 DAOA DAOA-AS1 12(6/0/6) 2
Association analysis:allele P-value = 0.494, OR=1.09, genot...... Association analysis:allele P-value = 0.494, OR=1.09, genotype P-value = 0.45, OR=1.21 More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Schumacher, J.,2004
Fisher P-value = 0.0143 for all, P-value = 0.9804 for SCZ O...... Fisher P-value = 0.0143 for all, P-value = 0.9804 for SCZ Only More... When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. More... Positive Detera-Wadleigh, S. D., 2006
rs10994336 ANK3 12(7/0/5) 4
Genotype association:CC P-value = 0.617, CT P-value = 0.689...... Genotype association:CC P-value = 0.617, CT P-value = 0.689, TT P-value = 0.62 for SZ. More... No significant association was observed. No significant association was observed. Negative Gella, A.,2011
All ethnicities: OR=0.98, 95%CI =0.78-1.23, P-value=0.840; ...... All ethnicities: OR=0.98, 95%CI =0.78-1.23, P-value=0.840; Malay: OR=0.62, 95%CI =0.40-0.95, P-value=0.029; Chinese: OR=1.05, 95%CI =0.76-1.46, P-value=0.776; Indian: OR=1.45, 95%CI =0.91-2.32, P-value=0.116 More... rs10994336 was significantly different between BPD and SZ p...... rs10994336 was significantly different between BPD and SZ patients and controls of Malay ethnicity(P= 0.001 and 0.012, for BPD and SZ, respectively). More... Positive Lim C.H., 2014
rs3918342 DAOA 11(4/0/7) 3
Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. More... Positive Detera-Wadleigh, S. D., 2006
chi-squared tests:for SCZ, allele, X2(1 d.f.)=5....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=5.824, P-value = 0.016 More... Significant association was observed in allelic association...... Significant association was observed in allelic association in SCZ. More... Positive Bass, N. J.,2009
rs778294 DAOA DAOA-AS1 10(3/0/7) 5
Association analysis:allele P-value = 0.27, OR=1.15, genoty...... Association analysis:allele P-value = 0.27, OR=1.15, genotype P-value = 0.504, OR=1.21 More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Schumacher, J.,2004
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.141, P-value = 0.707 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
rs1341402 DAOA DAOA-AS1 10(3/0/7) 3
allelic P-value = 0.82 in Schizophrenia allelic P-value = 0.82 in Schizophrenia We found no evidence for allelic or genotypic association w...... We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). More... Negative Williams, N. M., 2006
Association analysis:allele P-value = 0.352, OR=1.14, genot...... Association analysis:allele P-value = 0.352, OR=1.14, genotype P-value = 0.55, OR=1.48 More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Schumacher, J.,2004
rs947267 DAOA DAOA-AS1 9(1/0/8) 3
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.203, P-value = 0.652 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
Fisher P-value = 0.2256 for all, P-value = 0.9478 for SCZ O...... Fisher P-value = 0.2256 for all, P-value = 0.9478 for SCZ Only More... Negative Detera-Wadleigh, S. D., 2006
rs1421292 DAOA 8(2/0/6) 3
allelic P-value = 0.66 in Schizophrenia allelic P-value = 0.66 in Schizophrenia We found no evidence for allelic or genotypic association w...... We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). More... Negative Williams, N. M., 2006
Fisher P-value = 0.001 for all, P-value = 0.0092 for SCZ On...... Fisher P-value = 0.001 for all, P-value = 0.0092 for SCZ Only More... When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. More... Positive Detera-Wadleigh, S. D., 2006
rs1170191 DGKH 7(1/0/6) 1
Allelic association:P-value = 0.052, permutated P-value = 0...... Allelic association:P-value = 0.052, permutated P-value = 0.385 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs1935058 DAOA-AS1 DAOA 7(3/0/4) 2
allelic P-value = 0.52 in Schizophrenia allelic P-value = 0.52 in Schizophrenia We found no evidence for allelic or genotypic association w...... We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). More... Negative Williams, N. M., 2006
Fisher P-value = 0.0015 for all, P-value = 0.4416 for SCZ O...... Fisher P-value = 0.0015 for all, P-value = 0.4416 for SCZ Only More... When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. More... Positive Detera-Wadleigh, S. D., 2006
rs954581 DAOA-AS1 DAOA 7(0/0/7) 2
Fisher P-value = 0.5966 for all, P-value = 1 for SCZ Only Fisher P-value = 0.5966 for all, P-value = 1 for SCZ Only Negative Detera-Wadleigh, S. D., 2006
allelic P-value = 0.67 in Schizophrenia allelic P-value = 0.67 in Schizophrenia We found no evidence for allelic or genotypic association w...... We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). More... Negative Williams, N. M., 2006
rs165599 ARVCF COMT 7(5/0/2) 2
OR (95% CI)=1.13 (0.99-1.30) of males, OR (95% CI)=1.47 (1....... OR (95% CI)=1.13 (0.99-1.30) of males, OR (95% CI)=1.47 (1.22-1.77) of females More... previously found to be associated with schizophrenia previously found to be associated with schizophrenia Positive Shifman, S., 2004
Allelic association:for SCZ, P-value = 0.221, trend P-value...... Allelic association:for SCZ, P-value = 0.221, trend P-value = 0.24, OR (95%CI)=1.17(0.91, 1.51);for SCZ+SA, P-value = 0.16, trend P-value = 0.175, OR (95%CI)=1.18(0.94, 1.49) More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Funke, B.,2005
rs9834970 TRANK1 LRBA 6(3/2/1) 2
P-value=7.18E-05 for BP, P-value=5.53E-13 for BP+SZ, Het P-...... P-value=7.18E-05 for BP, P-value=5.53E-13 for BP+SZ, Het P-value=0.85 More... Most significant SNP in six genome-wide significant regions...... Most significant SNP in six genome-wide significant regions. More... Negative Ruderfer, D. M., 2013
Conditional FDR; BD loci given SCZ: FDR=0.02711 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.02711 for BD and SCZ||Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.027 for BD and SZ, Z-score=3.965 for SZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. This SNP is with conjunction FDR<0.08 with schizophrenia and bipolar disorder considered jointly. More... Positive Andreassen OA, 2013
rs3916965 DAOA 6(2/0/4) 2
Fisher P-value = 0.0001 for all, P-value = 0.0002 for SCZ O...... Fisher P-value = 0.0001 for all, P-value = 0.0002 for SCZ Only More... When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. More... Positive Detera-Wadleigh, S. D., 2006
chi-squared tests:for SCZ, allele, X2(1 d.f.)=2....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=2.101, P-value = 0.147 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
rs9804190 ANK3 6(2/0/4) 2
Genotype association:CC P-value = 0.949, CT P-value = 0.674...... Genotype association:CC P-value = 0.949, CT P-value = 0.674, TT P-value = 0.284 for SZ. More... No significant association was observed. No significant association was observed. Negative Gella, A.,2011
SCOPE sample:MAF=0.21, Cochrane-Mantel-Haenszel test P-valu...... SCOPE sample:MAF=0.21, Cochrane-Mantel-Haenszel test P-value = 0.88, Bonferroni corrected P-value = 1, OR (95%CI)=0.99(0.87-1.13);Icelandic sample:MAF(affected)=0.23, MAF(unaffected)=0.22, allelic P-value = 0.5, Bonferroni corrected P-value = 1, OR (95%CI)=1.05(0.92-1.20) More... No significant association was observed. No significant association was observed. Negative Tesli, M.,2011
rs778293 DAOA 6(2/0/4) 3
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.93, P-value = 0.335 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
allelic P-value = 0.44 in Schizophrenia allelic P-value = 0.44 in Schizophrenia We found no evidence for allelic or genotypic association w...... We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). More... Negative Williams, N. M., 2006
rs1012053 DGKH 6(1/0/5) 1
Allelic association:P-value = 0.074, permutated P-value = 0...... Allelic association:P-value = 0.074, permutated P-value = 0.494 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs1801260 CLOCK TMEM165 6(3/0/3) 1
chi-square test: 1. total samples:P-value = 0.321(Genotype)...... chi-square test: 1. total samples:P-value = 0.321(Genotype), P-value = 0.519(Allele) in SCZ 2. male samples: P-value = 0.856(Genotype), P-value = 0.680(Allele) in SCZ 3. female samples: P-value = 0.196(Genotype), P-value = 0.105(Allele) in SCZ More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs821616 DISC1 TSNAX 6(1/0/5) 3
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.5 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
SZ patients: P-value=0.179, P-value=0.213 for females, P-va...... SZ patients: P-value=0.179, P-value=0.213 for females, P-value=0.579 for males; BPAD&SCZ: P-value=0.04, P-value=0.138 for females, P-value=0.183 for males More... One SNP (rs821616) showed moderate significant association ...... One SNP (rs821616) showed moderate significant association with cases compared with controls in regression analysis More... Positive Ram Murthy, A., 2012
rs9315885 DGKH MAPK6PS3 6(0/0/6) 1
Allelic association:P-value = 0.014, permutated P-value = 0...... Allelic association:P-value = 0.014, permutated P-value = 0.127 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs4680 COMT 6(3/0/3) 2
OR (95% CI)=1.14 (0.99-1.32) of males, OR (95% CI)=1.09 (0....... OR (95% CI)=1.14 (0.99-1.32) of males, OR (95% CI)=1.09 (0.90-1.32) of females More... previously found to be associated with schizophrenia previously found to be associated with schizophrenia Positive Shifman, S., 2004
Allelic association:for SCZ, P-value = 0.419, trend P-value...... Allelic association:for SCZ, P-value = 0.419, trend P-value = 0.414, OR (95%CI)=1.1(0.87, 1.41);for SCZ+SA, P-value = 0.304, trend P-value = 0.299, OR (95%CI)=1.12(0.90, 1.40) More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Funke, B.,2005
rs3738401 DISC1 TSNAX 5(0/0/5) 2
SZ patients: P-value=0.794, P-value=0.473 for females, P-va...... SZ patients: P-value=0.794, P-value=0.473 for females, P-value=0.427 for males; BPAD&SCZ: P-value=0.520, P-value=0.875 for females, P-value=0.529 for males More... Negative Ram Murthy, A., 2012
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.15 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs1344706 ZNF804A 5(3/0/2) 3
P-value<0.00001, I2=71%, chi-square=100.88 df=29...... P-value<0.00001, I2=71%, chi-square=100.88 df=29, Heterrogeneity Tau2=0.01 More... In the subgroup analysis of diseases, we found a significan...... In the subgroup analysis of diseases, we found a significant associationbetween the T-allele of rs1344706 and schizophrenia in the random effect meta-analysis More... Positive Sun, Y., 2015
X2 tests:allele P-value = 0.31 for SCZ. X2 tests:allele P-value = 0.31 for SCZ. No significant association was observed. No significant association was observed. Negative Schanze, D.,2011
rs737865 COMT TXNRD2 5(2/0/3) 2
OR (95% CI)=1.19 (1.03-1.37) of males, OR (95% CI)=1.27 (1....... OR (95% CI)=1.19 (1.03-1.37) of males, OR (95% CI)=1.27 (1.04-1.54) of females More... previously found to be associated with schizophrenia previously found to be associated with schizophrenia Positive Shifman, S., 2004
Allelic association:for SCZ, P-value = 0.511, trend P-value...... Allelic association:for SCZ, P-value = 0.511, trend P-value = 0.518, OR (95%CI)=1.09(0.84, 1.41);for SCZ+SA, P-value = 0.438, trend P-value = 0.448, OR (95%CI)=1.1(0.87, 1.39) More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Funke, B.,2005
rs6746896 LMAN2L CNNM4 5(3/2/0) 1
All ethnicities: OR=1.34, 95%CI =1.12-1.61, P-value=0.001; ...... All ethnicities: OR=1.34, 95%CI =1.12-1.61, P-value=0.001; Malay: OR=1.50, 95%CI =1.07-2.10, P-value=0.020; Chinese: OR=1.21, 95%CI =0.94-1.55, P-value=0.148; Indian: OR=1.59, 95%CI =0.98-2.58, P-value=0.061 More... rs6746896 shows significant differences in allelic distribu...... rs6746896 shows significant differences in allelic distribution between both BPD and SZ patients and controls for the pooled subjects (P =0.009 and 0.001, respectively). More... Positive Lim C.H., 2014
rs420259 PALB2 5(3/0/2) 1
CMH test:P-value = 0.54, OR (95% CI)=1.04(0.91-1.20) for SC...... CMH test:P-value = 0.54, OR (95% CI)=1.04(0.91-1.20) for SCZ. More... No significant association was observed. No significant association was observed. Negative Tesli, M.,2010
rs2251219 PBRM1 SMIM4 RNU6-856P 5(5/0/0) 2
Association analysis:allele P-value = 0.21, OR=0.97 Association analysis:allele P-value = 0.21, OR=0.97 No significant association was observed in SZ. No significant association was observed in SZ. Negative Vassos, E.,2012
P-value = 0.0018,OR= 1.21;P-value = 0.0051,P-vorrection = 0...... P-value = 0.0018,OR= 1.21;P-value = 0.0051,P-vorrection = 0.01,OR = 1.13 for replication. More... Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs1938526 ANK3 5(3/0/2) 2
All ethnicities: OR=0.86, 95%CI =0.71-1.04, P-value=0.123; ...... All ethnicities: OR=0.86, 95%CI =0.71-1.04, P-value=0.123; Malay: OR=0.60, 95%CI =0.41-0.89, P-value=0.012; Chinese: OR=0.87, 95%CI =0.66-1.15, P-value=0.334; Indian: OR=1.21, 95%CI =0.79-1.83, P-value=0.384 More... rs1938526 was found to be significantly associated with BPD...... rs1938526 was found to be significantly associated with BPD and SZ. More... Positive Lim C.H., 2014
SCOPE sample:MAF=0.073, Cochrane-Mantel-Haenszel test P-val...... SCOPE sample:MAF=0.073, Cochrane-Mantel-Haenszel test P-value = 0.95, Bonferroni corrected P-value = 1, OR (95%CI)=0.99(0.81-1.22);Icelandic sample:MAF(affected)=0.06, MAF(unaffected)=0.058, allelic P-value = 0.32, Bonferroni corrected P-value = 0.96, OR (95%CI)=1.03(0.81-1.31) More... No significant association was observed. No significant association was observed. Negative Tesli, M.,2011
rs9371601 SYNE1 5(4/1/0) 1
Conditional FDR; BD loci given SCZ: FDR=0.02196 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.02196 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs766288 TSNAX DISC1 4(1/0/3) 2
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.72 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
SZ patients: P-value=0.906, P-value=0.03 for females, P-val...... SZ patients: P-value=0.906, P-value=0.03 for females, P-value=0.105 for males; BPAD&SCZ: P-value=0.336, P-value=0.004 for females, P-value=0.248 for males More... The most significant association was found for combined fem...... The most significant association was found for combined female cases of BPAD or SCZ. Moderate associations were also observed in females for rs766288 (SCZ, P=0.03) More... Positive Ram Murthy, A., 2012
rs1000731 DISC1 TSNAX 4(0/0/4) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.96 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs6313 HTR2A 4(0/0/4) 1
Overall: T vs. C (Allele frequency): OR=0.970, 95%CI=0.914-...... Overall: T vs. C (Allele frequency): OR=0.970, 95%CI=0.914-1.030, P-value=0.316; TT + TC vs. CC (Dominant): OR=0.970, 95%CI=0.888-1.059, P-value=0.495; TT vs. TC + CC (Recessive): OR=0.965, 95%CI=0.885-1.053, P-value=0.428; TT vs. TC (Codominant1): OR=0.982, 95%CI=0.921-1.047, P-value=0.578; TC vs. CC (Codominant2): OR=1.010, 95%CI=0.949-1.074, P-value=0.761; TT vs. CC (Homozygote): OR=0.948, 95%CI=0.838-1.073, P-value=0.397. Caucasian: T vs. C (Allele frequency): OR=0.994, 95%CI=0.903-1.093, P-value=0.894; TT + TC vs. CC (Dominant): OR=0.989, 95%CI=0.887-1.102, P-value=0.84; TT vs. TC + CC (Recessive): OR=0.989, 95%CI=0.838-1.167, P-value=0.895; TT vs. TC (Codominant1): OR=1.011, 95%CI=0.919-1.112, P-value=0.824; TC vs. CC (Codominant2): OR=1.018, 95%CI=0.940-1.102, P-value=0.664; TT vs. CC (Homozygote): OR=0.968, 95%CI=0.796-1.178, P-value=0.747. Asian: T vs. C (Allele frequency): OR=0.952, 95%CI=0.879-1.032, P-value=0.232; TT + TC vs. CC (Dominant): OR=0.956, 95%CI=0.822-1.113, P-value=0.564; TT vs. TC + CC (Recessive): OR=0.949, 95%CI=0.867-1.040, P-value=0.265; TT vs. TC (Codominant1): OR=0.951, 95%CI=0.870-1.038, P-value=0.261; TC vs. CC (Codominant2): OR=1.016, 95%CI=0.917-1.126, P-value=0.761; TT vs. CC (Homozygote): OR=0.933, 95%CI=0.786-1.106, P-value=0.423. Other/Mixed: T vs. C (Allele frequency): OR=0.929, 95%CI=0.742-1.164, P-value=0.523; TT + TC vs. CC (Dominant): OR=0.834, 95%CI=0.521-1.333, P-value=0.447; TT vs. TC + CC (Recessive): OR=1.034, 95%CI=0.719-1.486, P-value=0.856; TT vs. TC (Codominant1): OR=1.142, 95%CI=0.772-1.69, P-value=0.505; TC vs. CC (Codominant2): OR=0.769, 95%CI=0.525-1.128, P-value=0.179; TT vs. CC (Homozygote): OR=0.882, 95%CI=0.572-1.360, P-value=0.57. Chinese: T vs. C (Allele frequency): OR=0.990, 95%CI=0.925-1.059, P-value=0.77; TT + TC vs. CC (Dominant): OR=1.017, 95%CI=0.899-1.150, P-value=0.793; TT vs. TC + CC (Recessive): OR=0.967, 95%CI=0.875-1.069, P-value=0.516; TT vs. TC (Codominant1): OR=0.957, 95%CI=0.861-1.064, P-value=0.419; TC vs. CC (Codominant2): OR=1.032, 95%CI=0.905-1.176, P-value=0.64; TT vs. CC (Homozygote): OR=1.004, 95%CI=0.872-1.154, P-value=0.961 More... The results of our study indicate that theT102C polymorphis...... The results of our study indicate that theT102C polymorphism is not associates with increased susceptibility to SCZ. More... Negative Tan J., 2014
rs3916967 DAOA DAOA-AS1 4(2/0/2) 2
Fisher P-value = 0.0734 for all, P-value = 0.0734 for SCZ O...... Fisher P-value = 0.0734 for all, P-value = 0.0734 for SCZ Only More... Negative Detera-Wadleigh, S. D., 2006
chi-squared tests:for SCZ, allele, X2(1 d.f.)=3....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=3.675, P-value = 0.055 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
rs6675281 DISC1 TSNAX 4(0/0/4) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.57 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs3916966 DAOA-AS1 DAOA 4(1/0/3) 1
Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ O...... Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ Only More... When results are combined across studies and phenotypes, th...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. More... Positive Detera-Wadleigh, S. D., 2006
rs8192625 TAAR6 4(1/0/3) 1
Allele frequency (SZ vs.control) 0.02 vs. 0.01; P-value > ...... Allele frequency (SZ vs.control) 0.02 vs. 0.01; P-value > 0.05 More... Negative Pae, C. U., 2008
rs1538977 DISC1 TSNAX 4(0/0/4) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.98 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs7296288 DHH 4(3/1/0) 1
Conditional FDR; BD loci given SCZ: FDR=0.02777 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.02777 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs2919390 NRG1 3(2/0/1) 2
X2 test:P-value = 0.01 for Scottish 1, P-value =...... X2 test:P-value = 0.01 for Scottish 1, P-value = 0.92 for German More... Significant association was found. Significant association was found. Positive Walker, R. M.,2010
Individual P-value = 0.0096 for SCZ , Individual P-value = ...... Individual P-value = 0.0096 for SCZ , Individual P-value = 0.0105 for SCZ and BP More... This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample Positive Thomson, P. A., 2007
rs2812393 DISC1 TSNAX 3(1/0/2) 2
SZ patients: P-value=0.093, P-value=0.026 for females, P-va...... SZ patients: P-value=0.093, P-value=0.026 for females, P-value=0.775 for males; BPAD&SCZ: P-value=0.073, P-value=0.028 for females, P-value=0.668 for males More... Moderate associations were also observed in females for rs2...... Moderate associations were also observed in females for rs2812393 (SCZ, P=0.026; BPAD&SCZ, P=0.028). More... Positive Ram Murthy, A., 2012
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.6 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs1982350 ARNTL 3(2/0/1) 1
TDT P-value = 0.561, Trends test=0.255 for Pittsburgh SZ/SZ...... TDT P-value = 0.561, Trends test=0.255 for Pittsburgh SZ/SZA; case-control P-value = 0.028, X2=7.137, df=2 when contrasting genotype distributions More... Contrasting genotype distributions in cases with the popula...... Contrasting genotype distributions in cases with the population-based sample did not reveal any significant differences by the trend test, although the genotype distribution for ARNTL rs1982350 was noted to be significantly different. More... Positive Mansour, H. A., 2006
rs1630250 TSNAX DISC1 3(0/0/3) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.95 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs3918346 DAO DAOA 3(0/0/3) 2
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.976, P-value = 0.323 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
Diagnosisxgenotype interaction:in the left precuneus (Z-sco...... Diagnosisxgenotype interaction:in the left precuneus (Z-score=4.79, p=0.004 after FWE correction), which also expressed deactivation during generation relative to baseline across different diagnostic and genotypic groups.Exploration of the parameter estimates revealed that, in this region, deactivation during generation relative to baseline was less pronounced in schizophrenic patients with one or two copies of the T allele than those without it (Z-score=4.55, p=0.012 after FWE correction); in contrast the opposite trend was expressed amongst healthy volunteers (Zscore= 2.77, p<0.01 uncorrected)In the right posterior cingulate gyrus (Z-score=4.42, p=0.021 after FWE). In this region, there was activation during generation in patients with schizophrenia who had at least one copy of the T allele while there was deactivation in those without it (Z-score=5.11, p=0.001 after FWE) More... This revealed two regions which expressed a significant dia...... This revealed two regions which expressed a significant diagnosis×genotype interaction at p<0.05 after FEW correction for multiple comparisons. More... Positive Papagni, S. A.,2011
rs228729 VAMP3 PER3 3(0/0/3) 1
TDT P-value = 0.914, Trends test=0.028 for Pittsburgh SZ/SZ...... TDT P-value = 0.914, Trends test=0.028 for Pittsburgh SZ/SZA More... Negative Mansour, H. A., 2006
rs11191580 NT5C2 3(3/0/0) 2
Association analysis:OR=1.19, P-value = 0.01 Association analysis:OR=1.19, P-value = 0.01 Significant association was observed in SZ. Significant association was observed in SZ. Positive association was observed in SZ. Hamshere, M. L.,2012
Conditional FDR; SCZ loci given BD: P-value=0.00000171, FDR...... Conditional FDR; SCZ loci given BD: P-value=0.00000171, FDR=0.049, FDR=0.005 for SCZ and BD More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. More... Positive Andreassen OA, 2013
rs2295814 EGR2 ADO 3(1/0/2) 1
For SZ, chi-square tests:allele, OR=1.451, X2=3....... For SZ, chi-square tests:allele, OR=1.451, X2=3.1172, P-value = 0.0775, P-value(permutation)=0.3337;Fisher's exact test, genotype, X2=3.2943, P-value = 0.1926 More... No significant association was observed. No significant association was observed. Negative Kim, S. H.,2011
rs1322784 DISC1 TSNAX 3(0/0/3) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.56 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2535629 ITIH3 3(3/0/0) 2
Association analysis:P-value = 0.00000000000254,OR(95%CI) =...... Association analysis:P-value = 0.00000000000254,OR(95%CI) = 1.1(1.07–1.12) when five disorders were combined More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
Conditional FDR; BD loci given SCZ: FDR=0.00279 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.00279 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs4332037 MAD1L1 3(1/1/1) 1
Conditional FDR; BD loci given SCZ: FDR=0.02918 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.02918 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs6937506 TAAR6 3(0/0/3) 1
Allele frequency (SZ vs.control) 0.18 vs. 0.15; P-value > ...... Allele frequency (SZ vs.control) 0.18 vs. 0.15; P-value > 0.05 More... Negative Pae, C. U., 2008
rs2492367 DISC1 TSNAX 3(1/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.5 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2271893 LMAN2L 3(2/0/1) 2
All ethnicities: OR=1.24, 95%CI =0.99-1.56, P-value=0.060; ...... All ethnicities: OR=1.24, 95%CI =0.99-1.56, P-value=0.060; Malay: OR=2.63, 95%CI =1.40-4.97, P-value=0.003; Chinese: OR=0.86, 95%CI =0.64-1.15, P-value=0.297; Indian: OR=2.76, 95%CI =1.46-5.20, P-value=0.002 More... rs2271893 C allele frequency was significantly higher in SZ...... rs2271893 C allele frequency was significantly higher in SZ patients compared with healthy controls, a condition observed in Malays and Indians (P= 0.002 and P= 0.003, respectively). More... Positive Lim C.H., 2014
Conditional FDR; BD loci given SCZ: FDR=0.0096 for BD and S...... Conditional FDR; BD loci given SCZ: FDR=0.0096 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs3741775 DAO DAOA 3(0/0/3) 1
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.587, P-value = 0.444 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
rs2297488 EGR2 3(1/0/2) 1
For SZ, chi-square tests:allele, OR=1.114, X2=0....... For SZ, chi-square tests:allele, OR=1.114, X2=0.3127, P-value = 0.576, P-value(permutation)=0.5592;Fisher's exact test, genotype, X2=2.9107, P-value = 0.2333 More... No significant association was observed. No significant association was observed. Negative Kim, S. H.,2011
rs4650608 PTGFR IFI44L 3(2/0/1) 2
P-value=1.77E-04 for BP, P-value=5.53E-13 for BP+SZ, Het P-...... P-value=1.77E-04 for BP, P-value=5.53E-13 for BP+SZ, Het P-value=0.85 More... Most significant SNP in six genome-wide significant regions...... Most significant SNP in six genome-wide significant regions. More... Negative Ruderfer, D. M., 2013
Conditional FDR; SCZ loci given BD: P-value=0.000206, FDR=0...... Conditional FDR; SCZ loci given BD: P-value=0.000206, FDR=0.257, FDR=0.028 for SCZ and BD||Conditional FDR; BD loci given SCZ: FDR=0.0425 for BD and SCZ||Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.043 for BD and SZ, Z-score=3.711 for SZ More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.08. This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. This SNP is with conjunction FDR<0.06 with schizophrenia and bipolar disorder considered jointly. More... Positive Andreassen OA, 2013
rs334558 GSK3B 3(0/0/3) 1
Pheterogeneity=0.266, I2=23.2 %; OR=1...... Pheterogeneity=0.266, I2=23.2 %; OR=1.12, 95 % CI: 1.01, 1.25 More... C allele demonstrated more risk than T allele in schizophre...... C allele demonstrated more risk than T allele in schizophrenia. No evidence to imply the publication bias was observed by Begg’s funnel plot. And Egger's test further provided statistical support. More... Positive Tang, H., 2013
rs736408 ITIH3 3(1/2/0) 1
P-value = 0.021,OR= 0.874 P-value = 0.021,OR= 0.874 Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs6903874 TAAR6 3(1/0/2) 1
Allele frequency (SZ vs.control) 0.14 vs. 0.09; X2 Allele frequency (SZ vs.control) 0.14 vs. 0.09; X2(df=1)= 6.28, P-value = 0.012 More... The minor allele (C) of SNP rs6903874 was significantly ove...... The minor allele (C) of SNP rs6903874 was significantly over-represented among the patients with schizophrenia compared to controls. More... Positive Pae, C. U., 2008
rs1954175 DISC1 TSNAX 3(0/0/3) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.093 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2278749 ARNTL 3(1/0/2) 1
not analyzed for Pittsburgh SZ/SZA not analyzed for Pittsburgh SZ/SZA Negative Mansour, H. A., 2006
rs3736544 CLOCK TMEM165 3(1/0/2) 1
chi-square test: 1. total samples: P-value = 0.296(Genotype...... chi-square test: 1. total samples: P-value = 0.296(Genotype), P-value = 0.317(Allele) in SCZ 2. male samples: P-value = 0.830(Genotype), P-value = 0.985(Allele) in SCZ 3. female samples: P-value = 0.218(Genotype), P-value = 0.191(Allele) in SCZ More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs821597 DISC1 TSNAX 3(0/0/3) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.16 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs138880 BRD1 3(1/0/2) 2
P-value = 0.45, OR=1.09 in UK/DK sample P-value = 0.45, OR=1.09 in UK/DK sample Nominal significant association with SZ Nominal significant association with SZ Positive Nyegaard, M., 2010
P-value = 0.0061 in SZ, P-value = 0.0046 in BD and SZ P-value = 0.0061 in SZ, P-value = 0.0046 in BD and SZ The promoter SNP rs138880 showed association in SZ and the ...... The promoter SNP rs138880 showed association in SZ and the combined case group. More... Positive Severinsen, J. E., 2006 (b)
rs646558 NCAM1 3(1/0/2) 1
Fisher's exact test, allelic P-value = 1 in SZ; Fisher's ex...... Fisher's exact test, allelic P-value = 1 in SZ; Fisher's exact test, allelic P-value = 0.602 in BD&SZ; Heterozygous genotypic association (A/A-C/A): chi-square P-value = 0.01, X2=6.6, OR(95%CI)=0.054 (0.003-1.16); Homozygous genotypic association (C/C-A/A): chi-square P-value = 0.049, X2=3.86, OR(95%CI)=9.57 [0.47-193.92]; Allele positivity [(C/C+C/A)-A/A]: chi-square P-value = 0.027, X2=4.88, OR(95%CI)=0.084 [0.004-1.67] in SZ More... The SNP heterozygote and homozygote associations were signi...... The SNP heterozygote and homozygote associations were significant, as well as allele positivity for SZ, showing a suggestion of association. More... Positive Atz, M. E., 2007
rs1997644 CSNK1E 3(2/0/1) 2
Chi square test:MAF = 0.38,P-value = 0.89,OR = 0.99 Chi square test:MAF = 0.38,P-value = 0.89,OR = 0.99 No significant association was observed. No significant association was observed. Negative Matsunaga, S.,2012
Single SNP-based analyses:Trends test P-value = 0.363 in SZ Single SNP-based analyses:Trends test P-value = 0.363 in SZ No significant association was observed No significant association was observed Negative Mansour, H. A.,2009
rs715505 SYNGR1 3(1/0/2) 1
Fisher's exact test:allele P-value = 0.00007, chi-square te...... Fisher's exact test:allele P-value = 0.00007, chi-square test:genotype P-value = 0.0004 in SCZ More... Significant association was observed in allelic association...... Significant association was observed in allelic association. More... Positive Verma, R.,2005(a)
rs6988339 NRG1 3(2/0/1) 2
Individual P-value = 0.0103 for SCZ , Individual P-value = ...... Individual P-value = 0.0103 for SCZ , Individual P-value = 0.0058 for SCZ and BP More... This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample Positive Thomson, P. A., 2007
X2 test:P-value = 0.01 for Scottish 1, P-value =...... X2 test:P-value = 0.01 for Scottish 1, P-value = 0.55 for Scottish 2, P-value = 0.38 for German, P-value = 0.024 for merged Scottish, P-value = 0.22 for merged all More... Significant association was found. Significant association was found. Positive Walker, R. M.,2010
rs9315897 DGKH 3(0/0/3) 1
Allelic association:P-value = 0.583, permutated P-value = 1...... Allelic association:P-value = 0.583, permutated P-value = 1 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs2279574 DUSP6 3(3/0/0) 2
chi-square P-value = 0.9205, Permutation P-value = 0.9992, ...... chi-square P-value = 0.9205, Permutation P-value = 0.9992, X2=0.01, OR=1.012; chi-square P-value = 0.8087, Permutation P-value = 1, X2=0.0586, OR=1.047 for female subjects, chi-square P-value = 0.7677, Permutation P-value = 0.93, X2=0.0872, OR=0.954 for male subjects More... showed nominally significant allelic associations with BD, ...... showed nominally significant allelic associations with BD, but not with SPR, in female patients More... Negative Kim, S. H., 2012 (a)
allelic P-value = 0.911, genotypic P-value = 0.991 for tota...... allelic P-value = 0.911, genotypic P-value = 0.991 for total patients; allelic P-value = 0.95, genotypic P-value = 0.865 for male patients; allelic P-value = 0.776, genotypic P-value = 0.95 for female patients with schizophrenia More... G allele was not different between schizophrenic patients a...... G allele was not different between schizophrenic patients and controls. When allele and genotype distribution were compared between the bipolar and schizophrenia groups, no significant difference was found. However, G allele was observed more commonly in bipolar females than their schizophrenic counterparts. More... Negative Lee, K. Y., 2006 (a)
rs37022 SLC6A3 3(1/0/2) 1
Stanley sample:allele, X2 P-value = 0.81, Fisher...... Stanley sample:allele, X2 P-value = 0.81, Fisher's exact P-value = 0.86OR=0.91 for SZ More... No significant association was observed. No significant association was observed. Negative Pinsonneault, J. K.,2011
rs2282586 GRIK4 2(1/0/1) 1
P-value = 0.358 between SCZ cases and controls; P-value = 0...... P-value = 0.358 between SCZ cases and controls; P-value = 0.058 between all cases and controls More... Negative Pickard, B. S., 2006
rs6932590 POM121L2 2(1/0/1) 1
Association results in schizophrenia follow-up samples(10,6...... Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.10 (1.05, 1.14),P-value = 2.5 x 10-5 More... No significant association was observed. No significant association was observed. Negative Steinberg, S.,2012
rs901561 NRG1 2(1/0/1) 1
Individual P-value = 0.7958 for SCZ , Individual P-value = ...... Individual P-value = 0.7958 for SCZ , Individual P-value = 0.9163 for SCZ and BP More... Negative Thomson, P. A., 2007
rs1978340 GAD1 2(1/0/1) 1
Fisher's exact test:for SZ, in Scottish sample set, P-value...... Fisher's exact test:for SZ, in Scottish sample set, P-value(allele)=0.57, P-value(genotype)=0.74 More... No significant association was observed. No significant association was observed. Negative Lundorf, M. D.,2005
rs734551 DISC1 TSNAX 2(0/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.89 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2073831 BTF3P11 KCTD12 2(0/1/1) 1
All ethnicities: OR=1.07, 95%CI =0.90-1.28, P-value=0.445; ...... All ethnicities: OR=1.07, 95%CI =0.90-1.28, P-value=0.445; Malay: OR=0.68, 95%CI =0.49-0.95, P-value=0.025; Chinese: OR=1.35, 95%CI =1.04-1.74, P-value=0.024; Indian: OR=1.18, 95%CI =0.81-1.70, P-value=0.387 More... KCTD12 rs2073831 was significantly associated with SZ in Ma...... KCTD12 rs2073831 was significantly associated with SZ in Malays and Chinese (P= 0.024 and 0.025, respectively). More... Positive Lim C.H., 2014
rs988748 BDNF 2(0/0/2) 1
Armitage Trend Test:in Bonn sample, for Schizophrenia, P-va...... Armitage Trend Test:in Bonn sample, for Schizophrenia, P-value(odds ratio)=0.418(1.07) More... No significant association was observed. No significant association was observed. Negative Schumacher, J.,2005
rs3757930 NRG1 2(0/0/2) 2
X2 test:P-value = 0.2 for Scottish 1, P-value = ...... X2 test:P-value = 0.2 for Scottish 1, P-value = 0.69 for Scottish 2, P-value = 0.16 for German, P-value = 0.17 for merged Scottish, P-value = 0.85 for merged all More... No significant association was observed. No significant association was observed. Negative Walker, R. M.,2010
Individual P-value = 0.2035 for SCZ , Individual P-value = ...... Individual P-value = 0.2035 for SCZ , Individual P-value = 0.1164 for SCZ and BP More... Negative Thomson, P. A., 2007
rs10462021 PER3 2(0/0/2) 2
Single SNP-based analyses:Trends test P-value = 0.036 in SZ Single SNP-based analyses:Trends test P-value = 0.036 in SZ Significant association was observed Significant association was observed Positive Mansour, H. A.,2009
TDT P-value = 0.485, Trends test=0.913 for Pittsburgh SZ/SZ...... TDT P-value = 0.485, Trends test=0.913 for Pittsburgh SZ/SZA More... Negative Mansour, H. A., 2006
rs751229 DISC1 TSNAX 2(0/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.25 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs11098403 NDST3 2(1/0/1) 1
meta, P-value=2.67E-08 (OR=1.15, 95% confidence interval (C...... meta, P-value=2.67E-08 (OR=1.15, 95% confidence interval (CI): 1.08-1.21) when considering the schizophrenia cohorts alone; meta P-value=9.49E-12 (OR=1.13; 95% CI: 1.08-1.17) when all cohorts were included. Replication P-value=9.74E-04 for SZ when considering the non-discovery cohorts alone; Overall replication, P-value=1.46E-07; OR=1.09; 95% CI: 1.04-1.14 More... The top single-nucleotide polymorphism (SNP; rs11098403) de...... The top single-nucleotide polymorphism (SNP; rs11098403) demonstrates consistent effects across 11 replication and extension cohorts, totalling 23, 191 samples across multiple ethnicities, resulting in Pmeta=2.67 x 10(-8) (OR=1.15, 95% CI: 1.08-1.21) for schizophrenia alone. More... Positive Lencz, T., 2013
rs11736084 GPR78 2(0/0/2) 1
no P-value given in the text no P-value given in the text No single-marker association was detected. No single-marker association was detected. Negative Underwood, S. L., 2006
rs138855 BRD1 2(0/0/2) 2
P-value = 0.93, OR=1.01 in UK/DK sample P-value = 0.93, OR=1.01 in UK/DK sample Nominal significant association with SZ Nominal significant association with SZ Positive Nyegaard, M., 2010
P-value = 0.501 in SZ, P-value = 0.4186 in BD and SZ P-value = 0.501 in SZ, P-value = 0.4186 in BD and SZ Negative Severinsen, J. E., 2006 (b)
rs327329 NRG1 2(0/0/2) 2
X2 test:P-value = 0.44 for Scottish 1, P-value =...... X2 test:P-value = 0.44 for Scottish 1, P-value = 0.99 for Scottish 2, P-value = 0.56 for merged Scottish More... No significant association was observed. No significant association was observed. Negative Walker, R. M.,2010
Individual P-value = 0.4418 for SCZ , Individual P-value = ...... Individual P-value = 0.4418 for SCZ , Individual P-value = 0.7353 for SCZ and BP More... Negative Thomson, P. A., 2007
rs9799720 GPR78 2(1/0/1) 1
no P-value given in the text no P-value given in the text No single-marker association was detected. No single-marker association was detected. Negative Underwood, S. L., 2006
rs4532 DRD1 2(2/0/0) 2
no P-value provided no P-value provided With respect to schizophrenia, no significant association w...... With respect to schizophrenia, no significant association was found by a random effects model. More... Negative Zhang, J., 2013
no P-value no P-value With respect to schizophrenia, no significant association w...... With respect to schizophrenia, no significant association was found by a random effects model. More... Negative Yao, J., 2013
rs2020934 SLC6A4 2(0/0/2) 1
allelic P-value = 0.594, genotypic P-value = 0.161, Power c...... allelic P-value = 0.594, genotypic P-value = 0.161, Power calculation GRR=1.51 More... No associations of 'tagging' marker with SCZ was found. No associations of 'tagging' marker with SCZ was found. Negative Ikeda, M., 2006
rs553950 NRG1 2(2/0/0) 2
Individual P-value = 0.0288 for SCZ , Individual P-value = ...... Individual P-value = 0.0288 for SCZ , Individual P-value = 0.0109 for SCZ and BP More... This SNP is nominally significant in all three groups: BP, ...... This SNP is nominally significant in all three groups: BP, SCZ and combined. More... Positive Thomson, P. A., 2007
X2 test:P-value = 0.028 for Scottish 1, P-value ...... X2 test:P-value = 0.028 for Scottish 1, P-value = 0.99 for Scottish 2, P-value = 0.093 for merged Scottish More... Significant association was found. Significant association was found. Positive Walker, R. M.,2010
rs969486 ARNTL 2(1/0/1) 1
not analyzed for Pittsburgh SZ/SZA not analyzed for Pittsburgh SZ/SZA Negative Mansour, H. A., 2006
rs2076137 MLC1 2(0/0/2) 2
chi-square tests, P-value > 0.05 chi-square tests, P-value > 0.05 No association with the combined patient sample, SCZ or typ...... No association with the combined patient sample, SCZ or type A or type B schizophrenia was found. More... Negative Selch, S., 2007
Case-control association:for SCZ, Fisher exact test, allele...... Case-control association:for SCZ, Fisher exact test, allele P-value = 0.03; chi-square test, genotype P-value(additive)=0.02, P-value(dominant)=0.01, P-value(recessive)>0.05 ;Family-Based Association:for SCZ, TDT, P-value > 0.05 More... Significant association was observed in case-control associ...... Significant association was observed in case-control association analysis. More... Positive Verma, R.,2005(b)
rs6352 SLC6A4 2(0/0/2) 1
allelic P-value = 0.541, genotypic P-value = 0.911, Power c...... allelic P-value = 0.541, genotypic P-value = 0.911, Power calculation GRR=1.95 More... Asn605Lys showed weak association with SCZ, but the positiv...... Asn605Lys showed weak association with SCZ, but the positive association can not be confirmed in an additional analysis More... Negative Ikeda, M., 2006
rs769390 GAD1 2(0/0/2) 1
Fisher's exact test:for SZ, in Scottish sample set, P-value...... Fisher's exact test:for SZ, in Scottish sample set, P-value(allele)=0.8, P-value(genotype)=0.85 More... No significant association was observed. No significant association was observed. Negative Lundorf, M. D.,2005
rs133070 MCHR1 GAPDHP37 2(1/0/1) 1
CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ...... CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3638 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland More... In BPD and BPD/SZ combined, single marker association was o...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More... Positive Severinsen, J. E., 2006 (a)
rs1024582 CACNA1C CACNA1C-IT3 2(2/0/0) 1
Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.0...... Association analysis:P-value = 0.0000000187,OR(95%CI) = 1.07(1.05-1.10) when BD and SZ were combined More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
rs2241514 FEZ1 2(0/0/2) 2
Allelic P-value = 0.510, genotypic P-value = 0.788 in Cau...... Allelic P-value = 0.510, genotypic P-value = 0.788 in Caucasians. Allelic P-value = 0.911, genotypic P-value = 0.964 in African Americans. More... No association to schizophrenia was found for any of the ni...... No association to schizophrenia was found for any of the nine markers typed in these populations at the allelic or the genotypic level. More... Negative Hodgkinson, C. A., 2007
Association analysis:Fisher's exact test, allele P-value = ...... Association analysis:Fisher's exact test, allele P-value = 0.77, genotype P-value = 0.853 More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Yamada, K.,2004
rs61865882 EGR2 ADO 2(1/0/1) 1
For SZ, chi-square tests:allele, OR=1.27, X2=1.2...... For SZ, chi-square tests:allele, OR=1.27, X2=1.2985, P-value = 0.2545, P-value(permutation)=0.7578;Fisher's exact test, genotype, X2=1.5969, P-value = 0.45 More... No significant association was observed. No significant association was observed. Negative Kim, S. H.,2011
rs13440581 GPR50 GPR50-AS1 2(1/0/1) 1
Single marker association:for SCZ, allele P-value = 0.3(all...... Single marker association:for SCZ, allele P-value = 0.3(all), P-value = 0.84(male), P-value = 0.4(female) More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(b)
rs472913 NFIX 2(0/1/1) 1
P-value = 0.036,OR= 0.888 P-value = 0.036,OR= 0.888 Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs12966547 CCDC68 2(2/0/0) 2
Association analysis:P-value = 0.00000000026 when BPD,MDD a...... Association analysis:P-value = 0.00000000026 when BPD,MDD and SZ were combined. More... Significant association was observed in cross-disorder anal...... Significant association was observed in cross-disorder analysis. More... Positive Cross-Disorder Group of the Psychiatric Genomics Consortium,2013
Conditional FDR; SCZ loci given BD: P-value=0.00000623, FDR...... Conditional FDR; SCZ loci given BD: P-value=0.00000623, FDR=0.071, FDR=0.019 for SCZ and BD More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. More... Positive Andreassen OA, 2013
rs2494732 AKT1 SIVA1 2(1/0/1) 2
Association analysis:chi square=4.90;df=1;P-value = 0.02;P-...... Association analysis:chi square=4.90;df=1;P-value = 0.02;P-value(adjusted)>0.05;OR(95%CI)=1.57(1.0-2.3) More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Karege, F.,2012
single-locus analysis:z=1.73;P-value = 0.083 single-locus analysis:z=1.73;P-value = 0.083 No significant association was observed. No significant association was observed. Negative Karege, F.,2010
rs2709736 RPL23P8 SP8 2(1/1/0) 1
P-value = 0.025,OR= 0.871 P-value = 0.025,OR= 0.871 Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs3924999 NRG1 2(0/0/2) 1
For SZ:0.45/0.50 model:Pearson Chi-Square/P-value = 0.6/0.4...... For SZ:0.45/0.50 model:Pearson Chi-Square/P-value = 0.6/0.43, Yates Chi-Square/P-value = 10.28/0.25, Pearson Chi-Square/P-value = 10.55/0.21;Dominant model:Pearson Chi-Square/P-value = 0.08/0.77, Yates Chi-Square/P-value = 0.13/0.71, Pearson Chi-Square/P-value = 0.2/0.65 More... No significant association was observed. No significant association was observed. Negative Moon, E.,2011
rs133069 MCHR1 GAPDHP37 2(0/0/2) 1
CLUMP T1 P-value = 0.01, CLUMP T4 P-value = 0.01 for SZ; CL...... CLUMP T1 P-value = 0.01, CLUMP T4 P-value = 0.01 for SZ; CLUMP T1 P-value = 0.074, CLUMP T4 P-value = 0.074 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8734 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.7126 for BPD and SZ in the Case-Control Sample From Scotland More... The three GPR24 SNPs rs133068, rs133069, and rs133073 showe...... The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. More... Positive Severinsen, J. E., 2006 (a)
rs878567 HTR1A 2(1/0/1) 1
For SZ, chi-square tests:genotype, P-value = 0.0606, correc...... For SZ, chi-square tests:genotype, P-value = 0.0606, corrected P-value = 0.286;allele, P-value = 0.0238 More... No significant association was observed. No significant association was observed. Negative Kishi, T.,2011(b)
rs951266 CHRNA5 2(1/0/1) 1
P-value=0.15, OR=1.05, 95% CI=(1.02-1.18) in SZD; P-value=0...... P-value=0.15, OR=1.05, 95% CI=(1.02-1.18) in SZD; P-value=0.009, OR=1.07, 95% CI=(1.02-1.13) in SZD + BD; P-value=0.017, OR=1.19, 95% CI=(1.03-1.37) in SZD with the presence of negative symptoms of schizophrenia More... When the schizophrenia and bipolar disorder results were co...... When the schizophrenia and bipolar disorder results were combined, four markers, rs951266, rs16969968, rs8040868, and rs17487223, were significantly associated with risk for schizophrenia and bipolar disorder. A meta-analysis of the results revealed a significant association with the variants rs951266, rs1051730, rs8040868, and rs1748722, and the presence of negative symptoms. More... Positive Jackson, K. J., 2013
rs41279104 NOS1 2(0/0/2) 1
Association analysis:X2=2.9, genotypic P-value =...... Association analysis:X2=2.9, genotypic P-value = 0.58 More... No significant association was observed. No significant association was observed. Negative Silberberg, G.,2010
rs2709722 RPL23P8 SP8 2(1/1/0) 1
P-value = 0.0024,OR= 0.82;P-value = 0.049,P-vorrection = 0....... P-value = 0.0024,OR= 0.82;P-value = 0.049,P-vorrection = 0.098,OR = 0.922 for replication. More... Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs17025005 NPAS2 2(1/0/1) 1
Single SNP-based analyses:Trends test P-value = 0.085 in SZ Single SNP-based analyses:Trends test P-value = 0.085 in SZ No significant association was observed No significant association was observed Negative Mansour, H. A.,2009
rs12807809 NRGN 2(1/0/1) 1
Association results in schizophrenia follow-up samples(10,6...... Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.09 (1.04, 1.15),P-value = 0.00034 More... No significant association was observed. No significant association was observed. Negative Steinberg, S.,2012
rs11637898 ST8SIA2 2(2/0/0) 1
P-value > 0.075 P-value > 0.075 Single SNP analysis did not yield significant evidence for ...... Single SNP analysis did not yield significant evidence for association. More... Negative McAuley, E. Z., 2012
rs1615409 TSNAX DISC1 2(0/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.86 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2239848 BRD1 2(0/0/2) 2
P-value = 0.8, OR=0.9 in UK/DK sample P-value = 0.8, OR=0.9 in UK/DK sample Nominal significant association with SZ Nominal significant association with SZ Positive Nyegaard, M., 2010
P-value = 1 in SZ, P-value = 0.3983 in BD and SZ P-value = 1 in SZ, P-value = 0.3983 in BD and SZ Negative Severinsen, J. E., 2006 (b)
rs4279178 GABRB1 ADM 2(1/1/0) 1
Omnibus GWAS Test:P-value > 5E-05 Omnibus GWAS Test:P-value > 5E-05 No significant association was observed. No significant association was observed. Negative Huang, J.,2010
rs27072 SLC6A3 2(1/0/1) 1
Stanley sample:allele, X2 P-value = 0.91, Fisher...... Stanley sample:allele, X2 P-value = 0.91, Fisher's exact P-value = 1OR=1.05;U. of Bari sample X2 P-value = 0.69 for SZ More... No significant association was observed. No significant association was observed. Negative Pinsonneault, J. K.,2011
rs2702009 FEZ1 2(0/0/2) 2
Allelic P-value = 0.994, genotypic P-value = 0.900 in Cau...... Allelic P-value = 0.994, genotypic P-value = 0.900 in Caucasians. Allelic P-value = 0.962, genotypic P-value = 0.363 in African Americans. More... No association to schizophrenia was found for any of the ni...... No association to schizophrenia was found for any of the nine markers typed in these populations at the allelic or the genotypic level. More... Negative Hodgkinson, C. A., 2007
Association analysis:Fisher's exact test, allele P-value = ...... Association analysis:Fisher's exact test, allele P-value = 1, genotype P-value = 0.243 More... No significant association was observed in SZ. No significant association was observed in SZ. Negative Yamada, K.,2004
rs1800629 LTA TNF 2(1/0/1) 1
The frequency of the TNF -308G allele was 87.9% in SCH pati...... The frequency of the TNF -308G allele was 87.9% in SCH patients and 82.9% in control subjects, which was statistically significant (p = 0.008). The frequency of the TNF -308G/G genotype was significantly (p = 0.018) higher in patients than in controls (76.7 vs. 68.9%). More... Our results may point to an association of the TNF -308G al...... Our results may point to an association of the TNF -308G allele and -308G/G genotype with both SCH and BPAD, and to a relationship of the -308G allele with the risk of SCH and BPAD in patients with a positive family history. TNF could be potentially a susceptibility gene, shared between SCH and BPAD. More... Positive Czerski, P. M., 2008
rs2279287 ARNTL 2(1/0/1) 1
TDT P-value = 0.348, Trends test=0.173 for Pittsburgh SZ/SZ...... TDT P-value = 0.348, Trends test=0.173 for Pittsburgh SZ/SZA More... Negative Mansour, H. A., 2006
rs1538979 DISC1 2(1/0/1) 1
(CC+CT)>CC:for SZ, in the left postcentral gyrus (P-value c...... (CC+CT)>CC:for SZ, in the left postcentral gyrus (P-value corrected=0.001, z=4.39) for the sentence completion versus baseline. More... The schizophrenia group activation was significantly increa...... The schizophrenia group activation was significantly increased in those carrying the risk allele of rs1538979 compared to non-carriers in the left postcentral gyrus for the sentence completion versus baseline. More... Positive Chakirova, G.,2011
rs10776799 NGF 2(1/0/1) 1
Conditional FDR; BD loci given SCZ: FDR=0.02579 for BD and ...... Conditional FDR; BD loci given SCZ: FDR=0.02579 for BD and SCZ More... This SNP is with conditional FDR<0.05 in schizophrenia give...... This SNP is with conditional FDR<0.05 in schizophrenia given association with bipolar disorder after 'pruning'. More... Positive Andreassen OA, 2013
rs4468 BRD1 2(1/0/1) 2
P-value = 0.61, OR=1.05 in UK/DK sample P-value = 0.61, OR=1.05 in UK/DK sample Nominal significant association with SZ Nominal significant association with SZ Positive Nyegaard, M., 2010
P-value = 0.0088 in SZ, P-value = 0.0215 in BD and SZ P-value = 0.0088 in SZ, P-value = 0.0215 in BD and SZ SNP rs4468 and D22S1169 showed significant association with...... SNP rs4468 and D22S1169 showed significant association with SZ but not with BPD. More... Positive Severinsen, J. E., 2006 (b)
rs2235349 MLC1 2(1/0/1) 2
chi-square tests, P-value > 0.05 chi-square tests, P-value > 0.05 No association with the combined patient sample, SCZ or typ...... No association with the combined patient sample, SCZ or type A or type B schizophrenia was found. More... Negative Selch, S., 2007
Case-control association:for SCZ, Fisher exact test, allele...... Case-control association:for SCZ, Fisher exact test, allele P-value = 0.03; chi-square test, genotype P-value(additive)=0.02, P-value(dominant)=0.006, P-value(recessive)>0.05;Family-Based Association:for SCZ, TDT, P-value > 0.05 More... Significant association was observed in case-control associ...... Significant association was observed in case-control association analysis. More... Positive Verma, R.,2005(b)
rs7004633 MMP16 2(1/0/1) 2
Conditional FDR; SCZ loci given BD: P-value=0.00000017, FDR...... Conditional FDR; SCZ loci given BD: P-value=0.00000017, FDR=0.018, FDR=0.005 for SCZ and BD More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. More... Positive Andreassen OA, 2013
First-set screening: P-valuecorrected=0.65, P-va...... First-set screening: P-valuecorrected=0.65, P-value=0.0155, OR=0.83, 95%CI=0.71-0.96 More... Significant association was observed. Significant association was observed. Positive Saito T., 2014
rs4792938 GRN 2(1/0/1) 2
Tagging single nucleotide polymorphisms (SNPs) rs2879096 an...... Tagging single nucleotide polymorphisms (SNPs) rs2879096 and rs4792938, along with rs5848, previously shown to be associated with BD and schizophrenia More... Positive Galimberti, D., 2014
Association analysis:chi square test, genotype P-value = 0...... Association analysis:chi square test, genotype P-value = 0.002, OR: 0.48, 95%CI: 0.31-0.77;allele P-value > 0.05 More... Significant association was observed in SZ. Significant association was observed in SZ. Positive Galimberti, D.,2012
rs2038636 DISC1 TSNAX 2(0/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.83 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs3916971 DAOA-AS1 DAOA 2(0/0/2) 1
Fisher P-value = 0.0919 for all, P-value = 0.0919 for SCZ O...... Fisher P-value = 0.0919 for all, P-value = 0.0919 for SCZ Only More... Negative Detera-Wadleigh, S. D., 2006
rs613993 IMPA2 2(0/0/2) 1
Fisher's exact test, allelic P-value = 0.54, genotypic P-va...... Fisher's exact test, allelic P-value = 0.54, genotypic P-value = 0.628 More... Negative Ohnishi, T., 2007
rs1944522 GRIK4 2(0/0/2) 1
P-value = 0.842 between SCZ cases and controls; P-value = 0...... P-value = 0.842 between SCZ cases and controls; P-value = 0.405 between all cases and controls More... Negative Pickard, B. S., 2006
rs2297489 EGR2 2(1/0/1) 1
For SZ, chi-square tests:allele, OR=1.183, X2=0....... For SZ, chi-square tests:allele, OR=1.183, X2=0.7552, P-value = 0.3848, P-value(permutation)=0.909;Fisher's exact test, genotype, X2=2.1678, P-value = 0.3383 More... No significant association was observed. No significant association was observed. Negative Kim, S. H.,2011
rs7341475 RELN 2(0/0/2) 1
two-tail X2 test:GG genotype, P-value = 0.035 fo...... two-tail X2 test:GG genotype, P-value = 0.035 for females More... A significant effect was only seen in females. A significant effect was only seen in females. Positive Pisante, A.,2009
rs16969968 CHRNA3 CHRNA5 2(1/0/1) 1
P-value=0.09, OR=1.06, 95% CI=(0.97-1.13) in SZD; P-value=0...... P-value=0.09, OR=1.06, 95% CI=(0.97-1.13) in SZD; P-value=0.04, OR=1.06, 95% CI=(1-1.11) in SZD + BD; P-value=0.07, OR=1.15, 95% CI=(0.99-1.34) in SZD with the presence of negative symptoms of schizophrenia More... When the schizophrenia and bipolar disorder results were co...... When the schizophrenia and bipolar disorder results were combined, four markers, rs951266, rs16969968, rs8040868, and rs17487223, were significantly associated with risk for schizophrenia and bipolar disorder. More... Positive Jackson, K. J., 2013
rs133068 MCHR1 GAPDHP37 2(0/0/2) 1
CLUMP T1 P-value = 0.0197, CLUMP T4 P-value = 0.0197 for SZ...... CLUMP T1 P-value = 0.0197, CLUMP T4 P-value = 0.0197 for SZ; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8145 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland More... The three GPR24 SNPs rs133068, rs133069, and rs133073 showe...... The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. More... Positive Severinsen, J. E., 2006 (a)
rs2291739 TIMELESS ARHGEF5 2(1/0/1) 1
not analyzed for Pittsburgh SZ/SZA not analyzed for Pittsburgh SZ/SZA Negative Mansour, H. A., 2006
rs1509963 EGR2 ADO 2(0/0/2) 1
For SZ, chi-square tests:allele, OR=1.119, X2=0....... For SZ, chi-square tests:allele, OR=1.119, X2=0.8177, P-value = 0.3659, P-value(permutation)=0.8934;Fisher's exact test, genotype, X2=1.2583, P-value = 0.533 More... No significant association was observed. No significant association was observed. Negative Kim, S. H.,2011
rs9960767 TCF4 TCF7L2 2(0/0/2) 1
Association results in schizophrenia follow-up samples(10,6...... Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.14 (1.06, 1.23),P-value = 0.00057 More... No significant association was observed. No significant association was observed. Negative Steinberg, S.,2012
rs1705236 TSPAN8 2(0/1/1) 1
Cochran-Armitage test (dominant model):Bonferroni-Corrected...... Cochran-Armitage test (dominant model):Bonferroni-Corrected P-value = 1 More... No significant association was observed. No significant association was observed. Negative Scholz, C. J.,2010
rs3803300 ZBTB42 AKT1 2(2/0/0) 2
Association analysis:chi square=4.40;df=1;P-value = 0.04;P-...... Association analysis:chi square=4.40;df=1;P-value = 0.04;P-value(adjusted)>0.05;OR(95%CI)=2.11(1.0-4.4).Meta analysis:The p-value based on the z statistic was (z=4.75) P-value < 0.0001. More... Significant association was observed in SZ. Significant association was observed in SZ. Positive Karege, F.,2012
single-locus analysis:z=1.80;P-value = 0.072 single-locus analysis:z=1.80;P-value = 0.072 No significant association was observed. No significant association was observed. Negative Karege, F.,2010
rs2168351 ST8SIA2 2(2/0/0) 1
P-value > 0.075 P-value > 0.075 Single SNP analysis did not yield significant evidence for ...... Single SNP analysis did not yield significant evidence for association. More... Negative McAuley, E. Z., 2012
rs6010260 MLC1 2(0/0/2) 2
P-value = 0.0823 in SZ, P-value = 0.1631 in BD and SZ P-value = 0.0823 in SZ, P-value = 0.1631 in BD and SZ Negative Severinsen, J. E., 2006 (b)
Case-control association:for SCZ, Fisher exact test, allele...... Case-control association:for SCZ, Fisher exact test, allele P-value > 0.05; chi-square test, genotype P-value(additive)>0.05, P-value(dominant)>0.05, P-value(recessive)>0.05 ;Family-Based Association:for SCZ, TDT, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Verma, R.,2005(b)
rs909685 SYNGR1 2(1/0/1) 1
Fisher's exact test:allele P-value = 0.007, chi-square test...... Fisher's exact test:allele P-value = 0.007, chi-square test:genotype P-value = 0.025 in SCZ More... Significant association was observed in allelic association...... Significant association was observed in allelic association. More... Positive Verma, R.,2005(a)
rs1042779 ITIH1 2(1/1/0) 1
P-value = 0.012,OR= 1.16 P-value = 0.012,OR= 1.16 Significant association was observed. Significant association was observed. Positive Kondo, K.,2013
rs464049 SLC6A3 2(1/0/1) 1
Stanley sample:allele, X2 P-value = 0.88, Fisher...... Stanley sample:allele, X2 P-value = 0.88, Fisher's exact P-value = 1OR=0.96 for SZ More... No significant association was observed. No significant association was observed. Negative Pinsonneault, J. K.,2011
rs5848 GRN FAM171A2 2(1/0/1) 2
Tagging single nucleotide polymorphisms (SNPs) rs2879096 an...... Tagging single nucleotide polymorphisms (SNPs) rs2879096 and rs4792938, along with rs5848, previously shown to be associated with BD and schizophrenia More... Positive Galimberti, D., 2014
Association analysis:chi square test, genotype P-value = 0...... Association analysis:chi square test, genotype P-value = 0.01, OR: 0.51, 95%CI: 0.30-0.85;allele P-value < 0.0001, OR: 0.53, 95%CI: 0.39-0.72 More... Significant association was observed in SZ. Significant association was observed in SZ. Positive Galimberti, D.,2012
rs746187 DAOA 2(0/0/2) 1
Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ O...... Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only More... Negative Detera-Wadleigh, S. D., 2006
rs40184 SLC6A3 2(1/0/1) 1
Stanley sample:allele, X2 P-value = 0.61, Fisher...... Stanley sample:allele, X2 P-value = 0.61, Fisher's exact P-value = 0.64OR=1.17 for SZ More... No significant association was observed. No significant association was observed. Negative Pinsonneault, J. K.,2011
rs2759346 DISC1 TSNAX 2(1/0/1) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ...... Single-Marker Analysis:allele frequency, for SZ, P-value = 0.83 More... No significant association was observed. No significant association was observed. Negative Thomson, P. A.,2005(a)
rs2072621 GPR50 GPR50-AS1 2(0/0/2) 1
Single marker association:for SCZ, allele P-value = 0.31(al...... Single marker association:for SCZ, allele P-value = 0.31(all), P-value = 0.16(male), P-value = 0.0014(female) More... Association was not observed in SCZ, but was in observed S...... Association was not observed in SCZ, but was in observed SCZ(female). More... Negative Thomson, P. A.,2005(b)
rs6494223 CHRNA7 2(0/0/2) 1
Association analysis:allele P-value > 0.05, genotype P-valu...... Association analysis:allele P-value > 0.05, genotype P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Joo, E. J.,2010
rs3786282 IMPA2 2(0/0/2) 1
Fisher's exact test, allelic P-value = 0.965, genotypic P-v...... Fisher's exact test, allelic P-value = 0.965, genotypic P-value = 1 More... Negative Ohnishi, T., 2007
rs3749034 GAD1 2(0/0/2) 1
Fisher's exact test:for SZ, in Scottish sample set, P-value...... Fisher's exact test:for SZ, in Scottish sample set, P-value(allele)=0.61, P-value(genotype)=0.071 More... No significant association was observed. No significant association was observed. Negative Lundorf, M. D.,2005
rs1503491 NRG1 2(0/0/2) 2
X2 test:P-value = 0.61 for Scottish 1, P-value =...... X2 test:P-value = 0.61 for Scottish 1, P-value = 0.94 for Scottish 2, P-value = 0.86 for merged Scottish More... No significant association was observed. No significant association was observed. Negative Walker, R. M.,2010
Individual P-value = 0.609 for SCZ , Individual P-value = 0...... Individual P-value = 0.609 for SCZ , Individual P-value = 0.7019 for SCZ and BP More... Negative Thomson, P. A., 2007
rs2304672 PER2 2(1/0/1) 1
Single SNP-based analyses:Trends test P-value = 0.048 in SZ Single SNP-based analyses:Trends test P-value = 0.048 in SZ Significant association was observed Significant association was observed Positive Mansour, H. A.,2009
rs4356203 PIK3C2A 2(1/0/1) 2
P-value=2.14E-05 for BP, P-value=5.53E-13 for BP+SZ, Het P-...... P-value=2.14E-05 for BP, P-value=5.53E-13 for BP+SZ, Het P-value=0.85 More... Most significant SNP in six genome-wide significant regions...... Most significant SNP in six genome-wide significant regions. More... Negative Ruderfer, D. M., 2013
Conditional FDR; SCZ loci given BD: P-value=0.0000548, FDR=...... Conditional FDR; SCZ loci given BD: P-value=0.0000548, FDR=0.128, FDR=0.029 for SCZ and BD More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. More... Positive Andreassen OA, 2013
rs133073 MCHR1 2(0/0/2) 1
CLUMP T1 P-value = 0.0083, CLUMP T4 P-value = 0.0083 for SZ...... CLUMP T1 P-value = 0.0083, CLUMP T4 P-value = 0.0083 for SZ; CLUMP T1 P-value = 0.0546, CLUMP T4 P-value = 0.0546 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8469 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.5632 for BPD and SZ in the Case-Control Sample From Scotland More... The three GPR24 SNPs rs133068, rs133069, and rs133073 showe...... The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. More... Positive Severinsen, J. E., 2006 (a)
rs1053454 PIP4K2A 2(0/0/2) 1
ARMITAGE P-value = 0.430 for Schizophrenia ARMITAGE P-value = 0.430 for Schizophrenia In the single marker analysis, none of the analyzed variant...... In the single marker analysis, none of the analyzed variants revealed significant association to disease status, neither for schizophrenia nor for BPAD. More... Negative Jamra, R. A., 2006 (a)
rs909669 ADSL 2(1/0/1) 1
CLUMP T1 P-value = 0.1178, CLUMP T4 P-value = 0.1178 for SZ...... CLUMP T1 P-value = 0.1178, CLUMP T4 P-value = 0.1178 for SZ; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0655 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland More... In BPD and BPD/SZ combined, single marker association was o...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More... Positive Severinsen, J. E., 2006 (a)
rs6295 HTR1A 2(2/0/0) 1
For SZ, chi-square tests:genotype, P-value = 0.12;allele, P...... For SZ, chi-square tests:genotype, P-value = 0.12;allele, P-value = 0.146;meta analysis:random model:pooled OR=0.793, 95% CI=0.387-1.623, P(Z)=0.526 More... No significant association was observed. No significant association was observed. Negative Kishi, T.,2011(b)
rs2879096 GRN 2(1/0/1) 2
Tagging single nucleotide polymorphisms (SNPs) rs2879096 an...... Tagging single nucleotide polymorphisms (SNPs) rs2879096 and rs4792938, along with rs5848, previously shown to be associated with BD and schizophrenia More... Positive Galimberti, D., 2014
Association analysis:chi square test, genotype P-value = 0...... Association analysis:chi square test, genotype P-value = 0.0002, OR: 0.35, 95%CI: 0.20-0.61;allele P-value > 0.05 More... Significant association was observed in SZ. Significant association was observed in SZ. Positive Galimberti, D.,2012
rs1996147 EGR3 2(1/0/1) 1
Single SNP-based analyses:Trends test P-value = 0.193 in SZ Single SNP-based analyses:Trends test P-value = 0.193 in SZ No significant association was observed No significant association was observed Negative Mansour, H. A.,2009
rs13025524 NPAS2 2(1/0/1) 1
Single SNP-based analyses:Trends test P-value = 0.025 in SZ Single SNP-based analyses:Trends test P-value = 0.025 in SZ Significant association was observed Significant association was observed Positive Mansour, H. A.,2009
rs716934 DGKH 2(0/0/2) 1
Allelic association:P-value = 0.658, permutated P-value = 1...... Allelic association:P-value = 0.658, permutated P-value = 1 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs2111902 DAO DAOA 2(0/0/2) 1
chi-squared tests:for SCZ, allele, X2(1 d.f.)=0....... chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.025, P-value = 0.875 More... No significant association was observed. No significant association was observed. Negative Bass, N. J.,2009
rs597570 FEZ1 2(0/0/2) 2
Allelic P-value = 0.586, genotypic P-value = 0.696 in Cau...... Allelic P-value = 0.586, genotypic P-value = 0.696 in Caucasians. Allelic P-value = 0.858, genotypic P-value = 0.812 in African Americans. More... No association to schizophrenia was found for any of the ni...... No association to schizophrenia was found for any of the nine markers typed in these populations at the allelic or the genotypic level. More... Negative Hodgkinson, C. A., 2007
Association analysis:Fisher's exact test, allele P-value = ...... Association analysis:Fisher's exact test, allele P-value = 0.457, genotype P-value = 0.024 More... Significant associations were found in SZ patients. Significant associations were found in SZ patients. Positive Yamada, K.,2004
rs1050565 BLMH SLC6A4 2(0/0/2) 1
allelic P-value = 0.343, genotypic P-value = 0.139, Power c...... allelic P-value = 0.343, genotypic P-value = 0.139, Power calculation GRR=1.47 More... No associations of 'tagging' marker with SCZ was found. No associations of 'tagging' marker with SCZ was found. Negative Ikeda, M., 2006
rs3131296 NOTCH4 2(1/0/1) 1
Association results in schizophrenia follow-up samples(10,6...... Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.15 (1.08, 1.21),P-value = 1.4 x 10-6 More... Suggestive association was found. Suggestive association was found. Trend Steinberg, S.,2012
rs1051730 CHRNA3 2(0/0/2) 1
P-value=0.19, OR=1.05, 95% CI=(0.97-1.13) in SZD; P-value=0...... P-value=0.19, OR=1.05, 95% CI=(0.97-1.13) in SZD; P-value=0.08, OR=1.05, 95% CI=(0.99-1.1) in SZD + BD; P-value=0.019, OR=1.19, 95% CI=(1.03-1.37) in SZD with the presence of negative symptoms of schizophrenia More... A meta-analysis of the results revealed a significant assoc...... A meta-analysis of the results revealed a significant association with the variants rs951266, rs1051730, rs8040868, and rs1748722, and the presence of negative symptoms. More... Positive Jackson, K. J., 2013
rs7005606 NRG1 2(2/0/0) 1
Several allelic associations were found in the entire pool ...... Several allelic associations were found in the entire pool of BD, but not in schizophrenia. More... Negative Gutierrez-Fernandez, A., 2014
rs17844778 GPR78 2(0/0/2) 1
no P-value given in the text no P-value given in the text No single-marker association was detected. No single-marker association was detected. Negative Underwood, S. L., 2006
rs17693963 2(1/0/1) 2
Conditional FDR; SCZ loci given BD: P-value=0.000000187, FD...... Conditional FDR; SCZ loci given BD: P-value=0.000000187, FDR=0.022, FDR=0.001 for SCZ and BD More... To estimate the number of independent loci, we 'pruned' the...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.29. More... Positive Andreassen OA, 2013
P-value=3.27E-09 for BP, P-value=5.53E-13 for BP+SZ, Het P-...... P-value=3.27E-09 for BP, P-value=5.53E-13 for BP+SZ, Het P-value=0.85 More... Most significant SNP in six genome-wide significant regions...... Most significant SNP in six genome-wide significant regions. More... Positive Ruderfer, D. M., 2013
rs2076127 MLC1 2(0/0/2) 1
Case-control association:for SCZ, Fisher exact test, allele...... Case-control association:for SCZ, Fisher exact test, allele P-value > 0.05; chi-square test, genotype P-value(additive)>0.05, P-value(dominant)>0.05, P-value(recessive)>0.05 ;Family-Based Association:for SCZ, TDT, P-value = 0.004, major allele T/NT: 43/16 More... Significant association was observed in family based associ...... Significant association was observed in family based association analysis. More... Positive Verma, R.,2005(b)
rs3813034 SLC6A4 2(0/0/2) 1
allelic P-value = 0.557, genotypic P-value = 0.781, Power c...... allelic P-value = 0.557, genotypic P-value = 0.781, Power calculation GRR=1.49 More... No associations of 'tagging' marker with SCZ was found. No associations of 'tagging' marker with SCZ was found. Negative Ikeda, M., 2006
rs3916964 DAOA 2(0/0/2) 1
Fisher P-value = 0.1138 for all, P-value = 0.1138 for SCZ O...... Fisher P-value = 0.1138 for all, P-value = 0.1138 for SCZ Only More... Negative Detera-Wadleigh, S. D., 2006
rs9685931 GPR78 2(0/0/2) 1
no P-value given in the text no P-value given in the text No single-marker association was detected. No single-marker association was detected. Negative Underwood, S. L., 2006
rs2498804 AKT1 SIVA1 2(2/0/0) 1
single-locus analysis:z=2.47;P-value = 0.013 single-locus analysis:z=2.47;P-value = 0.013 Significant association was found. Significant association was found. Positive Karege, F.,2010
rs3749474 CLOCK TMEM165 2(0/0/2) 1
chi-square test: 1.total samples:P-value = 0.228(Genotype),...... chi-square test: 1.total samples:P-value = 0.228(Genotype), P-value = 0.412(Allele) in SCZ 2. male samples: P-value = 0.701(Genotype), P-value = 0.890(Allele) in SCZ 3. female samples: P-value = 0.181(Genotype), P-value = 0.345(Allele) in SCZ More... We did not find an association between these tag SNPs and J...... We did not find an association between these tag SNPs and Japanese schizophrenia, BP or MDD in any of the analyses. More... Negative Kishi, T.,2009(a)
rs1282 GPR78 2(1/0/1) 1
chi square allelic P-value = 0.044, OR (95% CI)=1.300 (1.00...... chi square allelic P-value = 0.044, OR (95% CI)=1.300 (1.006-1.679), genotypic P-value = 0.099, OR (95% CI)=2.164 (0.974-4.804) in SCZ; allelic P-value = 0.067, OR (95% CI)=1.233 (0.985-1.543), genotypic P-value = 0.142, OR (95% CI)=1.931 (0.932-4.002) in all cases; allelic P-value = 0.592, OR (95% CI)=1.093 (0.789-1.515), genotypic P-value = 0.862, OR (95% CI)=1.138 (0.415-3.121) in male SCZ; allelic P-value = 0.656, OR (95% CI)=1.070 (0.794-1.444), genotypic P-value = 0.905, OR (95% CI)=1.119 (0.443-2.827) in all male cases; allelic P-value = 0.015, OR (95% CI)=1.688 (1.104-2.581), genotypic P-value = 0.015, OR (95% CI)=5.991 (1.545-23.232) in female SCZ; allelic P-value = 0.035, OR (95% CI)=1.439 (1.025-2.021), genotypic P-value = 0.054, OR (95% CI)=3.976 (1.140-13.871) in all female cases More... Marginally significant allelic association was detected bet...... Marginally significant allelic association was detected between rs1282 (snp2) and SCZ; Only a trend toward significance (P<0.10) was detected between snp2 and SCZ at the genotype level; When restricting the allele and genotype frequency analysis to the female patients, a stronger association was detected between snp2 and SCZ; A weaker association was detected in the analysis of all affected females; The backwards logistic regression approach, where genotypes were declared as the independent variables and the model was adjusted for the effects of sex, confirmed the findings of the single-marker analysis. It identified SNP rs1282 as the only SNP to survive the variable selection and only in the SCZ model. More... Positive Underwood, S. L., 2006
rs11568190 MLC1 2(1/0/1) 1
Case-control association:for SCZ, Fisher exact test, allele...... Case-control association:for SCZ, Fisher exact test, allele P-value > 0.05; chi-square test, genotype P-value(additive)>0.05, P-value(dominant)>0.05, P-value(recessive)>0.05;Family-Based Association:for SCZ, TDT, P-value > 0.05 More... No significant association was observed. No significant association was observed. Negative Verma, R.,2005(b)
rs11123857 NPAS2 2(1/0/1) 1
Single SNP-based analyses:Trends test P-value = 0.038 in SZ Single SNP-based analyses:Trends test P-value = 0.038 in SZ Significant association was observed Significant association was observed Positive Mansour, H. A.,2009
rs2021722 TRIM26 2(2/0/0) 2
Association analysis:OR=1.17, P-value = 5.8E-04 Association analysis:OR=1.17, P-value = 5.8E-04 Significant association was observed in SZ. Significant association was observed in SZ. Positive association was observed in SZ. Hamshere, M. L.,2012
First-set screening: P-valuecorrected=0.32, P-va...... First-set screening: P-valuecorrected=0.32, P-value=0.00759, OR=0.76, 95%CI=0.62-0.93 More... Significant association was observed. Significant association was observed. Positive Saito T., 2014
rs1170098 DGKH 2(0/0/2) 1
Allelic association:P-value = 0.628, permutated P-value = 1...... Allelic association:P-value = 0.628, permutated P-value = 1 for SCZ More... No significant association was observed after permutation. No significant association was observed after permutation. Negative Zeng, Z.,2011
rs1411771 DISC1 TSNAX 2(0/0/2) 1
Single-Marker Analysis:allele frequency, for SZ, P-value = ......