SNP Report

Basic Info

Name	rs778293 dbSNP Ensembl
Location	chr13:105516850 - 105516850(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.434904
No. of Studies	6 (Positive: 2; Negative: 4; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 6)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Detera-Wadleigh, S. D., 2006	A/G	Fisher P-value = 0.0003 for all Fisher P-value = 0.0003 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
Maheshwari, M.,2009	G/A	TDT: Raw TDT P-value = 0.825, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.825, Adaptive permutation corrected P-value = 0.688 More...	No significant allelic association with BP was found No significant allelic association with BP was found	Negative
Williams, N. M., 2006		allelic P-value = 0.36, Gene-wide test P-value = 0.045 in Bi...... allelic P-value = 0.36, Gene-wide test P-value = 0.045 in Bipolar I Disorder More...	We observed significant evidence for whole-gene association ...... We observed significant evidence for whole-gene association (P=.04). More...	Negative
Zhang, Z.,2009(a)	A/G	Allelic association: Odds ratio (95% CI)=1.33(1.10-1.60), P-...... Allelic association: Odds ratio (95% CI)=1.33(1.10-1.60), P-value = 0.003 More...	Significant association was observed Significant association was observed	Positive
Grigoroiu-Serbanescu, M.,2010	A/G	Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.802, OR(95%CI)=1.08(0.60-1.93); for psychotic patients, P-value = 0.604, OR(95%CI)=0.92(0.67-1.25) More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Bass, N. J.,2009	A/G	chi-squared tests: for BP, allele, P-value > 0.05 chi-squared tests: for BP, allele, P-value > 0.05	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DAOA	D-amino acid oxidase activator	13q33.2	21(13/7/1)

SNPs in LD with rs778293 (count: 13) View in gBrowse (chr13:105504137..105527602 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 13)

rs_ID	Functional Annotation	r²[population]
rs7331364	intron_variant; non_coding_transcript_variant	0.845[CEU]
rs9519694		0.817[CEU]
rs9301038		0.817[CEU]
rs9519697		0.817[CEU]
rs778285		0.844[CEU]
rs1981271		0.817[CEU]
rs9519693		0.814[CEU]
rs1362886		0.809[CEU]
rs1642681		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs16966753		0.817[CEU]
rs810404		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs1981272		0.817[CEU]
rs778291		1.0[CEU]; 1.0[TSI]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 3)

Reference	Statistical Result	Description	Result Category
Bass, N. J.,2009	chi-squared tests:for SCZ, allele, X²(1 d.f.)=0.93, P-value = 0.335	No significant association was observed.	Negative
Williams, N. M., 2006	allelic P-value = 0.44 in Schizophrenia	We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04).	Negative
Detera-Wadleigh, S. D., 2006	Fisher P-value = 0.0003 for all, P-value = 0.0033 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive

Overlap with MDD from cross-disorder studies (count: 0)