SNP Report

Basic Info

Name	rs1503491 dbSNP Ensembl
Location	chr8:31784590 - 31784590(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.320487
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000518104, ENST00000519301, ENST00000520407, ENST00000523534)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007			Individual P-value = 0.2371 for BP, Individual P-value = 0.7...... Individual P-value = 0.2371 for BP, Individual P-value = 0.7019 for SCZ and BP More...		Negative
Walker, R. M.,2010			X² test: P-value = 0.24 for Scottish 1, P-value =...... X² test: P-value = 0.24 for Scottish 1, P-value = 0.61 for Scottish 2, P-value = 0.51 for merged Scottish More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs1503491 (count: 11) View in gBrowse (chr8:31751279..31838477 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2881272	intron_variant	0.911[CEU]
rs2345991	intron_variant	0.864[CEU]
rs4733272	intron_variant	0.954[CEU]
rs16878253	intron_variant	0.957[CEU]
rs1827537	intron_variant	0.825[CEU]
rs9642723	intron_variant	0.91[CEU]
rs2345989	intron_variant	0.913[CEU]
rs2062818	intron_variant	0.954[CEU]
rs937669	intron_variant	0.874[CEU]
rs2062817	intron_variant	0.957[CEU]
rs16878272	intron_variant	0.91[CEU]

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Walker, R. M.,2010	X² test:P-value = 0.61 for Scottish 1, P-value = 0.94 for Scottish 2, P-value = 0.86 for merged Scottish	No significant association was observed.	Negative
Thomson, P. A., 2007	Individual P-value = 0.609 for SCZ , Individual P-value = 0.7019 for SCZ and BP		Negative

Overlap with MDD from cross-disorder studies (count: 0)