BDgene

SNP Report

Basic Info
Name rs224278 dbSNP Ensembl
Location chr10:62820815 - 62820815(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.419529
Functional Annotation intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000493899); non_coding_transcript_variant(ENST00000493899); upstream_gene_variant(ENST00000242480, ENST00000411732, ENST00000439032, ENST00000637191, LRG_239t1)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Kim, S. H.,2011 T/C For BD, chi-square tests: allele, OR=1.121, X2=0....... For BD, chi-square tests: allele, OR=1.121, X2=0.9756, P-value = 0.3233, P-value(permutation)=0.8547; Fisher's exact test, genotype, X2=1.3887, P-value = 0.4994 More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
EGR2 early growth response 2 10q21.1 3(1/2/0)

SNPs in LD with rs224278 (count: 8) View in gBrowse (chr10:62820301..62834404 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 8)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Kim, S. H.,2011 For SZ, chi-square tests:allele, OR=0.979, X2=0.0268, P-value = 0.8698, P-value(permutation)=1;Fisher's exact test, genotype, X2=0.0339, P-value = 0.9832 No significant association was observed. Negative

Overlap with MDD from cross-disorder studies (count: 0)