BDgene

SNP Report

Basic Info
Name rs1170191 dbSNP Ensembl
Location chr13:42101357 - 42101357(1)
Variant Alleles A/G
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.248203
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000261491, ENST00000337343, ENST00000379274)
No. of Studies 7 (Positive: 1; Negative: 6; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 7)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Baum, A. E., 2008 (b) G Random effects P-value = 0.043; DerSimonian-Laird (random e...... Random effects P-value = 0.043; DerSimonian-Laird (random effects) OR (95% CI)=1.26 (1.01-1.61) More... Negative
Takata, A.,2011(a) C/T Fisher's exact test: allele P-value = 0.319, genotype P-valu...... Fisher's exact test: allele P-value = 0.319, genotype P-value = 0.443 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Squassina, A.,2009 C Alelle association: P-value = 0.312permutation P-value = 0.5...... Alelle association: P-value = 0.312permutation P-value = 0.551 More... No significant association was observed No significant association was observed Negative
Zeng, Z.,2011 C Allelic association: P-value = 0.179, permutated P-value = 0...... Allelic association: P-value = 0.179, permutated P-value = 0.81 for BPD; P-value = 0.292, permutated P-value = 0.944 for BPDI More... No significant association was observed in BD. No significant association was observed in BD. Negative
Baum, A. E., 2008 (a) C P-value = 0.003 when genotyped individually in the test samp...... P-value = 0.003 when genotyped individually in the test sample (NIMH); P-value = 0.0003 when individually genotyped in the Replication sample (German); P-value = 3.7E-08 in the combined dataset. OR (95% CI)=1.42 (1.23-1.65) More... significant at the P < 0.05 level in both samples. significant at the P < 0.05 level in both samples. Positive
Yosifova, A.,2009 A/G Allelic association: P-value = 0.91 Allelic association: P-value = 0.91 No significant association was observed No significant association was observed Negative
Ollila, H. M.,2009 G/A FBAT: P-value = 0.141857 FBAT: P-value = 0.141857 No significant association was observed No significant association was observed Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DGKH diacylglycerol kinase, eta 13q13.3 6(3/3/0)

SNPs in LD with rs1170191 (count: 23) View in gBrowse (chr13:42082705..42201303 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 23)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Zeng, Z.,2011 Allelic association:P-value = 0.052, permutated P-value = 0.385 for SCZ No significant association was observed after permutation. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Zeng, Z.,2011 Allelic association:P-value > 0.05 for MDD. No significant association was observed after permutation. Negative