Gene Report

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Basic Info

Approved Symbol	TXNL1
Previous Symbol	TXNL
Symbol Alias	Txl, TRP32
Approved Name	thioredoxin-like 1
Previous Name	thioredoxin-like, 32kDa
Name Alias	thioredoxin-like, 32kD
Location	18q21.31
Position	chr18:56597208-56651600, -1
External Links	HGNC: 12436 Entrez Gene: 9352 Ensembl: ENSG00000091164 UCSC: uc002lgg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs11875674	Suggestive association was found in BD-II.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0015036	disulfide oxidoreductase activity	molecular function	IDA[9668102]	1
GO:0006457	protein folding	biological process	IBA	7
GO:0006662	glycerol ether metabolic process	biological process	IEA	1
GO:0000103	sulfate assimilation	biological process	IBA	1
GO:0015035	protein disulfide oxidoreductase activity	molecular function	IBA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0055114	oxidation-reduction process	biological process	IBA	43
GO:0034599	cellular response to oxidative stress	biological process	IBA	7
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	molecular function	IBA	1
GO:0045454	cell redox homeostasis	biological process	IBA	4
GO:0000502	proteasome complex	cellular component	IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TXNL1	SUMO4	NO	in vivo	16236267

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11875674	chr18:56467257 - 56467257(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 8)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18q	chr18:18500000-80373285	1 (0/1/0)
18q12.3-q21.1	chr18:39500000-63900000	1 (1/0/0)
18q12-21	chr18:27500000-63900000	1 (0/1/0)
18q12.3-q22.1	chr18:39500000-69100000	1 (0/1/0)
18q21	chr18:45900000-63900000	3 (2/1/0)
18q21-23	chr18:45900000-80373285	1 (1/0/0)
18q21-q22	chr18:45900000-75400000	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

View in gBrowse

Region: chr18:56597208..56651600 View in gBrowse