SNP Report

Basic Info

Name	rs11637898 dbSNP Ensembl
Location	chr15:92409620 - 92409620(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.456869
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000268164, ENST00000539113, ENST00000555434)
No. of Studies	2 (Positive: 2; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
McAuley, E. Z., 2012	A/G		P-value = 0.048, Empirical P-value = 0.064, OR (95% CI)=0.75...... P-value = 0.048, Empirical P-value = 0.064, OR (95% CI)=0.75 (0.56-0.99) in the Australian bipolar disorder cohort More...	Nominally significant association (P < 0.05) was found with ...... Nominally significant association (P < 0.05) was found with 18 SNPs. More...	Positive
Yang, S. Y., 2015			P-value=0.005,Â OR=1.641, 95%CI=1.162-2.319 P-value=0.005,Â OR=1.641, 95%CI=1.162-2.319	The strongest association was observed in rs11637898 for sch...... The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	15q26	2(2/0/0)

SNPs in LD with rs11637898 (count: 14) View in gBrowse (chr15:92409620..92436217 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs1869777	intron_variant; upstream_gene_variant	0.812[CEU]
rs3931230	intron_variant; upstream_gene_variant	0.848[CEU]; 0.8[TSI]; 0.874[CHB]
rs3887775	intron_variant	0.924[CEU]
rs3848155	intron_variant; upstream_gene_variant	0.812[CEU]
rs3825985	intron_variant	0.874[CHB]
rs2892364	downstream_gene_variant; intron_variant	0.811[CEU]
rs10162611	intron_variant	0.961[CEU]
rs3902203	intron_variant; upstream_gene_variant	0.812[CEU]
rs3848153	downstream_gene_variant; intron_variant; upstream_gene_variant	0.819[CHB]
rs11632521	intron_variant; non_coding_transcript_variant	0.835[CEU]
rs3825986	intron_variant; upstream_gene_variant	0.848[CEU]; 0.888[TSI]
rs4777977	intron_variant; upstream_gene_variant	0.848[CEU]; 0.844[TSI]
rs4777979	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.819[CHB]
rs8026158	intron_variant; upstream_gene_variant	0.848[CEU]; 0.872[TSI]; 0.819[CHB]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
McAuley, E. Z., 2012	P-value > 0.075	Single SNP analysis did not yield significant evidence for association.	Negative

Overlap with MDD from cross-disorder studies (count: 0)