BDgene

SNP Report

Basic Info
Name rs133070 dbSNP Ensembl
Location chr22:40678769 - 40678769(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele G
Minor Allele Frequence 0.381589
Functional Annotation 5_prime_UTR_variant; upstream_gene_variant.
Consequence to Transcript 5_prime_UTR_variant(ENST00000249016); upstream_gene_variant(ENST00000381433, ENST00000442317, ENST00000465662, ENST00000498400)
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) A/G CLUMP T1 P-value = 0.0195, CLUMP T4 P-value = 0.0195 for BPD...... CLUMP T1 P-value = 0.0195, CLUMP T4 P-value = 0.0195 for BPD; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.9373 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland More... In BPD and BPD/SZ combined, single marker association was ob...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More... Positive
Yosifova, A.,2009 A/G Allelic association: P-value = 0.51 Allelic association: P-value = 0.51 No significant association was observed No significant association was observed Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MCHR1 melanin-concentrating hormone receptor 1 22q13.3 2(1/1/0)
GAPDHP37 glyceraldehyde 3 phosphate dehydrogenase pseudogene 37 22q13.2 Mapped by Literature SNP

SNPs in LD with rs133070 (count: 3) View in gBrowse (chr22:40670883..40678769 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3638 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. Positive

Overlap with MDD from cross-disorder studies (count: 0)