SNP Report

Basic Info

Name	rs133070 dbSNP Ensembl
Location	chr22:40678769 - 40678769(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	G
Minor Allele Frequence	0.381589
Functional Annotation	5_prime_UTR_variant; upstream_gene_variant.
Consequence to Transcript	5_prime_UTR_variant(ENST00000249016); upstream_gene_variant(ENST00000381433, ENST00000442317, ENST00000465662, ENST00000498400)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Severinsen, J. E., 2006 (a)	A/G		CLUMP T1 P-value = 0.0195, CLUMP T4 P-value = 0.0195 for BPD...... CLUMP T1 P-value = 0.0195, CLUMP T4 P-value = 0.0195 for BPD; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.9373 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland More...	In BPD and BPD/SZ combined, single marker association was ob...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More...	Positive
Yosifova, A.,2009	A/G		Allelic association: P-value = 0.51 Allelic association: P-value = 0.51	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MCHR1	melanin-concentrating hormone receptor 1	22q13.3	2(1/1/0)
GAPDHP37	glyceraldehyde 3 phosphate dehydrogenase pseudogene 37	22q13.2	Mapped by Literature SNP

SNPs in LD with rs133070 (count: 3) View in gBrowse (chr22:40670883..40678769 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs133064	upstream_gene_variant	0.918[CEU]; 0.976[TSI]
rs12172281	downstream_gene_variant	0.92[CEU]; 0.879[TSI]
rs133063	upstream_gene_variant	0.921[CEU]; 0.906[TSI]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Severinsen, J. E., 2006 (a)	CLUMP T1 P-value = 0.2107, CLUMP T4 P-value = 0.2107 for SZ; CLUMP T1 P-value = 0.0116, CLUMP T4 P-value = 0.0116 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3638 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.6721 for BPD and SZ in the Case-Control Sample From Scotland	In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037.	Positive

Overlap with MDD from cross-disorder studies (count: 0)