BDgene

SNP Report

Basic Info
Name rs954581 dbSNP Ensembl
Location chr13:105499917 - 105499917(1)
Variant Alleles T/C
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.119609
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000448407); non_coding_transcript_variant(ENST00000448407)
No. of Studies 7 (Positive: 0; Negative: 7; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 7)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Grigoroiu-Serbanescu, M.,2010 A/G Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.733, OR(95%CI)=0.84(0.34-2.09; for psychotic patients, P-value = 0.694, OR(95%CI)=0.91(0.58-1.44) More... No significant association was observed in BD. No significant association was observed in BD. Negative
Bass, N. J.,2009 C/T chi-squared tests: for BP, allele, X2(1 d.f.)=3.2...... chi-squared tests: for BP, allele, X2(1 d.f.)=3.221, P-value = 0.073 More... No significant association was observed. No significant association was observed. Negative
Williams, N. M., 2006 allelic P-value = 0.88, Gene-wide test P-value = 0.045 in Bi...... allelic P-value = 0.88, Gene-wide test P-value = 0.045 in Bipolar I Disorder More... We observed significant evidence for whole-gene association ...... We observed significant evidence for whole-gene association (P=.04). More... Negative
Maheshwari, M.,2009 C/T TDT: Raw TDT P-value = 0.313, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.313, Adaptive permutation corrected P-value = 1 More... No significant allelic association with BP was found No significant allelic association with BP was found Negative
Chen, Y. S.,2004 T/C Single-marker association results: Likelihood ratio statisti...... Single-marker association results: Likelihood ratio statistic is 0.1297, P-value > 0.05, OR=0.91 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Hattori, E.,2003 C/T T Association analysis: for CNG pedigrees, TDT P-value = 0.62,...... Association analysis: for CNG pedigrees, TDT P-value = 0.62, Transmission Ratio=0.57; for NIMH pedigrees, TDT P-value = 0.11, Transmission Ratio=0.65 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Detera-Wadleigh, S. D., 2006 C/T Fisher P-value = 0.5966 for all, P-value = 0.8368 for BP Onl...... Fisher P-value = 0.5966 for all, P-value = 0.8368 for BP Only More... Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs954581 (count: 5) View in gBrowse (chr13:105474537..105501610 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 5)


Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.5966 for all, P-value = 1 for SCZ Only Negative
Williams, N. M., 2006 allelic P-value = 0.67 in Schizophrenia We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). Negative

Overlap with MDD from cross-disorder studies (count: 0)