SNP Report

Basic Info

Name	rs2235698 dbSNP Ensembl
Location	chrCHR_HSCHR6_MHC_QBL_CTG1:29587920 - 29587920(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.26897
Functional Annotation	downstream_gene_variant; intron_variant; synonymous_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000441979); intron_variant(ENST00000355973); synonymous_variant(ENST00000383640, ENST00000441976, ENST00000449163, ENST00000453513, ENST00000441745, ENST00000438094, ENST00000439874, ENST00000424801, ENST00000417759, ENST00000411574, ENST00000439361, ENST00000448754, ENST00000454628, ENST00000417611, ENST00000383543, ENST00000383546, ENST00000453334, ENST00000383639, ENST00000376947)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Bergen, S. E.,2012		A	logistic regression: P-value > E-05 logistic regression: P-value > E-05	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	6p21.3	Mapped by Literature SNP

SNPs in LD with rs2235698 (count: 3) View in gBrowse (chrCHR_HSCHR6_MHC_QBL_CTG1:29577350..29621809 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs29221	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 0.874[TSI]
rs29220	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]
rs362522	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 0.874[TSI]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Bergen, S. E.,2012	logistic regression:for SZ full sample, OR=0.8, P-value = 8.59E-06	No significant association was observed in SZ.	Negative

Overlap with MDD from cross-disorder studies (count: 0)