SNP Report

Basic Info

Name	rs10995315 dbSNP Ensembl
Location	chr10:62814811 - 62814811(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.0894569
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000242480, ENST00000411732, ENST00000439032, ENST00000493899, ENST00000637191, LRG_239t1); non_coding_transcript_variant(ENST00000493899)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Kim, S. H.,2011	G/A		For BD, chi-square tests: allele, OR=1.664, X²=9....... For BD, chi-square tests: allele, OR=1.664, X²=9.5297, P-value = 0.002, P-value(permutation)=0.0127; Fisher's exact test, genotype, X²=9.9742, P-value = 0.0068 More...	Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
EGR2	early growth response 2	10q21.1	3(1/2/0)

SNPs in LD with rs10995315 (count: 4) View in gBrowse (chr10:62789094..62831852 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs11818600	downstream_gene_variant	0.811[JPT]
rs10995317	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[JPT]
rs10995321	intron_variant; non_coding_transcript_variant	0.911[CHB]; 1.0[JPT]
rs11817939	intron_variant; non_coding_transcript_variant	0.911[CHB]; 1.0[CHD]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Kim, S. H.,2011	For SZ, chi-square tests:allele, OR=1.116, X²=0.3138, P-value = 0.5754, P-value(permutation)=0.99;Fisher's exact test, genotype, X²=2.8926, P-value = 0.2354	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)