SNP Report

Basic Info

Name	rs4757142 dbSNP Ensembl
Location	chr11:13304148 - 13304148(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.409744
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000389707, ENST00000401424, ENST00000403290, ENST00000403510, ENST00000480685, ENST00000482049, ENST00000527998, ENST00000529050, ENST00000529388, ENST00000529825, ENST00000530357, ENST00000533520, ENST00000534544); non_coding_transcript_variant(ENST00000480685)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Mansour, H. A., 2006	G/A		TDT P-value = 0.597 in the samples combined, Pittsburgh Tren...... TDT P-value = 0.597 in the samples combined, Pittsburgh Trends test=0.0008 for BDI More...	For the contrasts of genotype distributions for individuals ...... For the contrasts of genotype distributions for individuals from the Pittsburgh sample diagnosed with BD1 vs. the population in general, significant differences were detected. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	11p15	7(5/2/0)

SNPs in LD with rs4757142 (count: 3) View in gBrowse (chr11:13304148..13314379 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs11022762	intron_variant; non_coding_transcript_variant	0.831[CEU]
rs10741616	intron_variant; non_coding_transcript_variant	0.831[CEU]
rs4757144	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.831[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Mansour, H. A., 2006	not analyzed for Pittsburgh SZ/SZA		Negative

Overlap with MDD from cross-disorder studies (count: 0)