Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADM
Symbol Alias	AM
Approved Name	adrenomedullin
Location	11p15.4
Position	chr11:10304680-10307397, 1
External Links	HGNC: 259 Entrez Gene: 133 Ensembl: ENSG00000148926 UCSC: uc001mil.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs4279178	The strongest result was seen for a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fitting model indicating that the effect was specific to bipolar II disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 48)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	TAS[8074714]	37
GO:0007565	female pregnancy	biological process	IEA	15
GO:0005179	hormone activity	molecular function	IEA	12

GO terms by database search (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2001214	positive regulation of vasculogenesis	biological process	IEA	1
GO:0031102	neuron projection regeneration	biological process	IEA	3
GO:0007507	heart development	biological process	IEA	20
GO:0009409	response to cold	biological process	IEA	7
GO:0042594	response to starvation	biological process	IEA	8
GO:0008284	positive regulation of cell proliferation	biological process	IEA	44
GO:0042475	odontogenesis of dentin-containing tooth	biological process	IEA	8
GO:0031623	receptor internalization	biological process	IDA[10882736]	5
GO:0030819	positive regulation of cAMP biosynthetic process	biological process	IDA[10882736]	5
GO:0043116	negative regulation of vascular permeability	biological process	IEA	1
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0005737	cytoplasm	cellular component	IDA[12379507]	322
GO:0060670	branching involved in labyrinthine layer morphogenesis	biological process	IEA	3
GO:0006701	progesterone biosynthetic process	biological process	TAS[10822232]	1
GO:0008015	blood circulation	biological process	TAS[8074714]	6
GO:0019933	cAMP-mediated signaling	biological process	IEA	6
GO:0002031	G-protein coupled receptor internalization	biological process	IDA[10882736]	4
GO:0031100	organ regeneration	biological process	IEA	5
GO:0006171	cAMP biosynthetic process	biological process	IDA[20074556]	6
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0048589	developmental growth	biological process	IEA	7
GO:0032868	response to insulin	biological process	IEA	10
GO:0060712	spongiotrophoblast layer development	biological process	IEA	1
GO:0007267	cell-cell signaling	biological process	TAS[8074714]	29
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	21
GO:0009611	response to wounding	biological process	IEA	9
GO:0008209	androgen metabolic process	biological process	IEA	4
GO:0007165	signal transduction	biological process	TAS[10822232]	136
GO:0005615	extracellular space	cellular component	IDA[12379507]	85
GO:0031700	adrenomedullin receptor binding	molecular function	IEA	1
GO:0002026	regulation of the force of heart contraction	biological process	IEA	5
GO:0032496	response to lipopolysaccharide	biological process	IEA	22
GO:0097084	vascular smooth muscle cell development	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[20074556]	563
GO:0001843	neural tube closure	biological process	IEA	8
GO:0045766	positive regulation of angiogenesis	biological process	IEA	11
GO:0045906	negative regulation of vasoconstriction	biological process	IDA[11410113]	1
GO:0051384	response to glucocorticoid	biological process	IEA	11
GO:0001570	vasculogenesis	biological process	IDA[16964401]	4
GO:0046879	hormone secretion	biological process	IEA	1
GO:0007568	aging	biological process	IEA	22
GO:0043065	positive regulation of apoptotic process	biological process	IEA	25
GO:0005576	extracellular region	cellular component	TAS	97
GO:0010460	positive regulation of heart rate	biological process	IEA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADM	CFH	NO	in vitro	11116141
ADM	MME	NO	in vitro	8687431
ADM	EDN1	NO	in vivo	11410113
ADM	CALCRL	NO	in vitro;in vivo	9620797

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4279178	chr4:47066563 - 47066563(1)	intron_variant; NMD_transcript_variant	2(1/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)
11p15.4	chr11:2800000-11700000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	genomewide significant evidence of cross-disorder effects was not detected	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	genomewide significant evidence of cross-disorder effects was not detected	Negative

Overlap with MDD from candidate gene intersection analysis (count: 2)

Reference	Description	Category in MDD	Link in MK4MDD
23064081		Pos	ADM
24424390	Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls	Pos	ADM

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Region: chr11:10304680..10307397 View in gBrowse