Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADM
Symbol Alias	AM
Approved Name	adrenomedullin
Location	11p15.4
Position	chr11:10304680-10307397, 1
External Links	HGNC: 259 Entrez Gene: 133 Ensembl: ENSG00000148926 UCSC: uc001mil.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs4279178	The strongest result was seen for a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fitting model indicating that the effect was specific to bipolar II disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 48)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	TAS[8074714]	37
GO:0007565	female pregnancy	biological process	IEA	15
GO:0005179	hormone activity	molecular function	IEA	12

GO terms by database search (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2001214	positive regulation of vasculogenesis	biological process	IEA	1
GO:0031102	neuron projection regeneration	biological process	IEA	3
GO:0007507	heart development	biological process	IEA	20
GO:0009409	response to cold	biological process	IEA	7
GO:0042594	response to starvation	biological process	IEA	8
GO:0008284	positive regulation of cell proliferation	biological process	IEA	44
GO:0042475	odontogenesis of dentin-containing tooth	biological process	IEA	8
GO:0031623	receptor internalization	biological process	IDA[10882736]	5
GO:0030819	positive regulation of cAMP biosynthetic process	biological process	IDA[10882736]	5
GO:0043116	negative regulation of vascular permeability	biological process	IEA	1
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0005737	cytoplasm	cellular component	IDA[12379507]	322
GO:0060670	branching involved in labyrinthine layer morphogenesis	biological process	IEA	3
GO:0006701	progesterone biosynthetic process	biological process	TAS[10822232]	1
GO:0008015	blood circulation	biological process	TAS[8074714]	6
GO:0019933	cAMP-mediated signaling	biological process	IEA	6
GO:0002031	G-protein coupled receptor internalization	biological process	IDA[10882736]	4
GO:0031100	organ regeneration	biological process	IEA	5
GO:0006171	cAMP biosynthetic process	biological process	IDA[20074556]	6
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0048589	developmental growth	biological process	IEA	7
GO:0032868	response to insulin	biological process	IEA	10
GO:0060712	spongiotrophoblast layer development	biological process	IEA	1
GO:0007267	cell-cell signaling	biological process	TAS[8074714]	29
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	21
GO:0009611	response to wounding	biological process	IEA	9
GO:0008209	androgen metabolic process	biological process	IEA	4
GO:0007165	signal transduction	biological process	TAS[10822232]	136
GO:0005615	extracellular space	cellular component	IDA[12379507]	85
GO:0031700	adrenomedullin receptor binding	molecular function	IEA	1
GO:0002026	regulation of the force of heart contraction	biological process	IEA	5
GO:0032496	response to lipopolysaccharide	biological process	IEA	22
GO:0097084	vascular smooth muscle cell development	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[20074556]	563
GO:0001843	neural tube closure	biological process	IEA	8
GO:0045766	positive regulation of angiogenesis	biological process	IEA	11
GO:0045906	negative regulation of vasoconstriction	biological process	IDA[11410113]	1
GO:0051384	response to glucocorticoid	biological process	IEA	11
GO:0001570	vasculogenesis	biological process	IDA[16964401]	4
GO:0046879	hormone secretion	biological process	IEA	1
GO:0007568	aging	biological process	IEA	22
GO:0043065	positive regulation of apoptotic process	biological process	IEA	25
GO:0005576	extracellular region	cellular component	TAS	97
GO:0010460	positive regulation of heart rate	biological process	IEA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADM	EDN1	NO	in vivo	11410113
ADM	MME	NO	in vitro	8687431
ADM	CALCRL	NO	in vitro;in vivo	9620797
ADM	CFH	NO	in vitro	11116141

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4279178	chr4:47066563 - 47066563(1)	intron_variant; NMD_transcript_variant	2(1/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)
11p15.4	chr11:2800000-11700000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	genomewide significant evidence of cross-disorder effects was not detected	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	genomewide significant evidence of cross-disorder effects was not detected	Negative

Overlap with MDD from candidate gene intersection analysis (count: 2)

Reference	Description	Category in MDD	Link in MK4MDD
23064081		Pos	ADM
24424390	Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls	Pos	ADM

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Region: chr11:10304680..10307397 View in gBrowse