SNP Report

Basic Info

Name	rs13440581 dbSNP Ensembl
Location	chrX:151181399 - 151181399(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.273377
Functional Annotation	missense_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000218316) SIFT Annotation: tolerated - low confidence(ENST00000218316)
Consequence to Transcript	missense_variant(ENST00000218316); upstream_gene_variant(ENST00000454196, ENST00000602313)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Thomson, P. A.,2005(b)	Val/Ile		Single marker association: for BPAD, allele P-value = 0.24(a...... Single marker association: for BPAD, allele P-value = 0.24(all), P-value = 0.74(male), P-value = 0.077(female); for BPAD+BPspec, allele P-value = 0.044(female) More...	Significant association was observed in BPAD, BPAD(female) a...... Significant association was observed in BPAD, BPAD(female) and BPAD+Bpspec(female). More...	Positive
Macintyre, D. J.,2010	A/G		X² goodness of fit test: P-value > 0.05 X² goodness of fit test: P-value > 0.05	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
GPR50-AS1	GPR50 antisense RNA 1	Xq28	Mapped by Literature SNP
GPR50	G protein-coupled receptor 50	Xq28	3(2/1/0)

SNPs in LD with rs13440581 (count: 0) View in gBrowse (chrX:151181399..151181399 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Thomson, P. A.,2005(b)	Single marker association:for SCZ, allele P-value = 0.3(all), P-value = 0.84(male), P-value = 0.4(female)	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Macintyre, D. J.,2010	X² goodness of fit test:P-value > 0.05	No significant association was observed.	Negative
Thomson, P. A.,2005(b)	Single marker association:for MDD, allele P-value = 0.04(all), P-value = 0.99(male), P-value = 0.0096(female)	Association was observed in MDD and MDD(female).	Positive